Variation in the Safety of Induced Pluripotent Stem Cell Lines

Overview

Journal Nat Biotechnol

Specialty Biotechnology

Date 2009 Jul 11

PMID 19590502

Citations 372

Authors

Kyoko Miura

Yohei Okada

Takashi Aoi

Aki Okada

Kazutoshi Takahashi

Keisuke Okita

Masato Nakagawa

Michiyo Koyanagi

Koji Tanabe

Mari Ohnuki

Daisuke Ogawa

Eiji Ikeda

Hideyuki Okano

Shinya Yamanaka

Affiliations

Soon will be listed here.

Abstract

We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells.

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