Relationship of Glomerular Filtration Rate Based on Serum Iodixanol Clearance to IRIS Staging in Cats with Chronic Kidney Disease

Overview

Journal J Vet Med Sci

Specialty Veterinary Medicine

Date 2015 Apr 14

PMID 25864431

Authors

Ryosuke Iwama

Tsubasa Sato

Masaaki Katayama

Shunsuke Shimamura

Hiroshi Satoh

Toshihiro Ichijo

Kazuhisa Furuhama

Affiliations

Soon will be listed here.

Abstract

We examined the correlation between the glomerular filtration rate (GFR) estimated from an equation based on the serum iodixanol clearance technique and International Renal Interest Society (IRIS) stages of chronic kidney disease (CKD) in cats. The equation included the injection dose, sampling time, serum concentration and estimated volume of distribution (Vd) of the isotonic, nonionic, contrast medium iodixanol as a test tracer. The percent changes in the median basal GFR values calculated from the equation in CKD cats resembled those of IRIS stages 1-3. These data validate the association between the GFR derived from the simplified equation and IRIS stages based on the serum creatinine concentration in cats with CKD. They describe the GFR ranges determined using single-sample iodixanol clearance for healthy cats and cats with various IRIS stages of CKD.

References

Svaland M, Haider T, Langseth-Manrique K, Andrew E, Hals P . Human pharmacokinetics of iodixanol. Invest Radiol. 1992; 27(2):130-3. DOI: 10.1097/00004424-199202000-00007. View

Jacobsen P, Blindheim L, Skotland T . Bioanalytical methods for iodixanol and their application to studies on metabolism and protein binding. Acta Radiol Suppl. 1995; 399:61-6. DOI: 10.1177/0284185195036s39908. View

Heglund I, Michelet A, Blazak W, Furuhama K, Holtz E . Preclinical pharmacokinetics and general toxicology of iodixanol. Acta Radiol Suppl. 1995; 399:69-82. DOI: 10.1177/0284185195036s39909. View

Von Hendy-Willson V, Pressler B . An overview of glomerular filtration rate testing in dogs and cats. Vet J. 2010; 188(2):156-65. PMC: 2980797. DOI: 10.1016/j.tvjl.2010.05.006. View

Katayama R, Saito J, Katayama M, Yamagishi N, Yamashita T, Kato M . Simplified procedure for the estimation of glomerular filtration rate following intravenous administration of iodixanol in cats. Am J Vet Res. 2012; 73(9):1344-9. DOI: 10.2460/ajvr.73.9.1344. View

Jacobsson L . A method for the calculation of renal clearance based on a single plasma sample. Clin Physiol. 1983; 3(4):297-305. DOI: 10.1111/j.1475-097x.1983.tb00712.x. View

Finch N, Heiene R, Elliott J, Syme H, Peters A . A single sample method for estimating glomerular filtration rate in cats. J Vet Intern Med. 2013; 27(4):782-90. DOI: 10.1111/jvim.12089. View

Katayama M, Sasaki A, Takayasu M, Shimamura S, Uzuka Y, Murayama I . Application of the single blood sample method to estimate feline glomerular filtration rate in a clinically relevant situation. J Feline Med Surg. 2013; 15(12):1119-22. PMC: 10816463. DOI: 10.1177/1098612X13492165. View

. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002; 39(2 Suppl 1):S1-266. View

10.

Mutzel W, Speck U . Pharmacokinetics and biotransformation of iohexol in the rat and the dog. Acta Radiol Suppl. 1980; 362:87-92. View

11.

Ross L, Finco D . Relationship of selected clinical renal function tests to glomerular filtration rate and renal blood flow in cats. Am J Vet Res. 1981; 42(10):1704-10. View

12.

Katayama M, Saito J, Katayama R, Yamagishi N, Murayama I, Miyano A . A single-blood-sample method using inulin for estimating feline glomerular filtration rate. J Vet Intern Med. 2012; 27(1):17-21. DOI: 10.1111/jvim.12017. View