What is the Most Realistic Single-compartment Model of Spike Initiation?

Overview

Journal PLoS Comput Biol

Specialty Biology

Date 2015 Apr 10

PMID 25856629

Citations 27

Authors

Romain Brette

Affiliations

Soon will be listed here.

Abstract

A large variety of neuron models are used in theoretical and computational neuroscience, and among these, single-compartment models are a popular kind. These models do not explicitly include the dendrites or the axon, and range from the Hodgkin-Huxley (HH) model to various flavors of integrate-and-fire (IF) models. The main classes of models differ in the way spikes are initiated. Which one is the most realistic? Starting with some general epistemological considerations, I show that the notion of realism comes in two dimensions: empirical content (the sort of predictions that a model can produce) and empirical accuracy (whether these predictions are correct). I then examine the realism of the main classes of single-compartment models along these two dimensions, in light of recent experimental evidence.

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