Alpha 2.0
Login Register
» Articles » PMID: 25847364

T2 Relaxation Times Are Increased in Skeletal Muscle of DMD but Not BMD Patients

Overview
Journal Muscle Nerve
Date 2015 Apr 8
PMID 25847364
Citations 25
Authors
Beatrijs H Wokke
Janneke C van den Bergen
Melissa T Hooijmans
Jan J Verschuuren
Erik H Niks
Hermien E Kan
Affiliations
Soon will be listed here.
Abstract

Introduction: Exon-skipping drugs in Duchenne muscular dystrophy (DMD) aim to restore truncated dystrophin expression, which is present in the milder Becker muscular dystrophy (BMD). MRI skeletal muscle T2 relaxation times as a representation of edema/inflammation could be quantitative outcome parameters for such trials.

Methods: We studied T2 relaxation times, adjusted for muscle fat fraction using Dixon MRI, in lower leg muscles of DMD and BMD patients and healthy controls.

Results: T2 relaxation times correlated significantly with fat fractions in patients only (P < 0.001). After adjusting for muscle fat, T2 relaxation times were significantly increased in 6 muscles of DMD patients (P < 0.01), except for the extensor digitorum longus. In BMD, T2 relaxation times were unchanged.

Conclusions: T2 relaxation times could be a useful outcome parameter in exon-skipping trials in DMD but are influenced by fat despite fat suppression. This should be accounted for when using quantitative T2 mapping to investigate edema/inflammation.

Citing Articles

A deep learning approach for fast muscle water T2 mapping with subject specific fat T2 calibration from multi-spin-echo acquisitions.

Barbieri M, Hooijmans M, Moulin K, Cork T, Ennis D, Gold G Sci Rep. 2024; 14(1):8253.

PMID: 38589478 PMC: 11002020. DOI: 10.1038/s41598-024-58812-2.

Compositional and Functional MRI of Skeletal Muscle: A Review.

Hooijmans M, Schlaffke L, Bolsterlee B, Schlaeger S, Marty B, Mazzoli V J Magn Reson Imaging. 2023; 60(3):860-877.

PMID: 37929681 PMC: 11070452. DOI: 10.1002/jmri.29091.

Using MRI to quantify skeletal muscle pathology in Duchenne muscular dystrophy: A systematic mapping review.

Alic L, Griffin 4th J, Eresen A, Kornegay J, Ji J Muscle Nerve. 2020; 64(1):8-22.

PMID: 33269474 PMC: 8247996. DOI: 10.1002/mus.27133.

Global versus individual muscle segmentation to assess quantitative MRI-based fat fraction changes in neuromuscular diseases.

Reyngoudt H, Marty B, Boisserie J, Le Louer J, Koumako C, Baudin P Eur Radiol. 2020; 31(6):4264-4276.

PMID: 33219846 DOI: 10.1007/s00330-020-07487-0.

Multi-parametric MR in Becker muscular dystrophy patients.

Hooijmans M, Froeling M, Koeks Z, Verschuuren J, Webb A, Niks E NMR Biomed. 2020; 33(11):e4385.

PMID: 32754921 PMC: 7687231. DOI: 10.1002/nbm.4385.