Gastric Mixed Adenoneuroendocrine Carcinoma with Thyroid Transcription Factor-1-positive Neuroendocrine Component

Overview

Journal Clin J Gastroenterol

Specialty Gastroenterology

Date 2015 Apr 1

PMID 25823931

Citations 1

Authors

Emi Yamaguchi

Yoshitoshi Sato

Takafumi Oe

Takeshi Nishi

Makoto Koike

Yasuhito Kitakado

Kenji Takubo

Affiliations

Soon will be listed here.

Abstract

Small cell carcinoma of the stomach, which is considered synonymous with neuroendocrine carcinoma, is rare. We encountered a case of mixed adenoneuroendocrine carcinoma. Gastrointestinal endoscopy revealed a type 0 IIa + IIc lesion in the stomach. Biopsy suggested well-differentiated adenocarcinoma. Endoscopic submucosal dissection was performed and gastric cancer comprising both well to moderately differentiated adenocarcinoma within the mucous membrane and small cell carcinoma invading to the submucosa with accompanying vessel invasion was found. Mixed adenoneuroendocrine carcinoma was diagnosed and the small cell carcinoma was thyroid transcription factor-1 positive. No tumor lesions were apparent in other organs, so distal gastrectomy and lymph node dissection were performed. Lymph node metastases were not observed. The patient is currently alive without recurrence. Thyroid transcription factor-1-positive gastric neuroendocrine carcinoma is very rare, and the thyroid transcription factor-1-positive rate may contribute to the prediction of prognosis and treatment selection. Accumulation of cases is thus very important.

Citing Articles

Clinical characteristics of early neuroendocrine carcinoma in stomach: A case report and review of literature.

Zhu X, Jing H, Yao T Medicine (Baltimore). 2019; 98(30):e16638.

PMID: 31348317 PMC: 6709248. DOI: 10.1097/MD.0000000000016638.

References

Hosokawa A, Shimada Y, Shirao K, Matsumura Y, Yamada Y, Muro K . Long-term survivor of gastric small cell carcinoma. Hepatogastroenterology. 2004; 51(59):1567-70. View

Tsushima T, Tsuji Y, Abe S, Tamura F, Mizushima T, Nagashima H . [A case of metastatic gastric endocrine cell carcinoma which could be curably resected after chemotherapy with S-1/CDDP]. Gan To Kagaku Ryoho. 2008; 35(5):817-20. View

Poiana C, Carsote M, Ardeleanu C, Terzea D, Avramescu E, Neamtu M . The value of the immunohistochemistry in a case of gastric neuroendocrine tumor and thyroid metastasis. Rom J Morphol Embryol. 2011; 52(1):187-92. View

Agoff S, Lamps L, Philip A, Amin M, Schmidt R, True L . Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol. 2000; 13(3):238-42. DOI: 10.1038/modpathol.3880044. View

Hanada N, Inoue K, Osako T, Kuriwaki K, Shimajiri S, Mochinaga M . [A case of partial response in liver metastatic lesion from gastric endocrine cell carcinoma treated with TS-1]. Gan To Kagaku Ryoho. 2006; 33(8):1143-6. View

Yamashina M, Flinner R . Concurrent occurrence of adenocarcinoma and carcinoid tumor in the stomach: a composite tumor or collision tumors?. Am J Clin Pathol. 1985; 83(2):233-6. DOI: 10.1093/ajcp/83.2.233. View

Chiba N, Suwa T, Hori M, Sakuma M, Kitajima M . Advanced gastric endocrine cell carcinoma with distant lymph node metastasis: a case report and clinicopathological characteristics of the disease. Gastric Cancer. 2004; 7(2):122-7. DOI: 10.1007/s10120-004-0279-2. View

Matsusaka T, Watanabe H, Enjoji M . Oat-cell carcinoma of the stomach. Fukuoka Igaku Zasshi. 1976; 67(2):65-73. View

Matsui T, Kataoka M, Sugita Y, Itoh T, Ichihara T, HORISAWA M . A case of small cell carcinoma of the stomach. Hepatogastroenterology. 1997; 44(13):156-60. View

10.

Namikawa T, Kobayashi M, Okabayashi T, Ozaki S, Nakamura S, Yamashita K . Primary gastric small cell carcinoma: report of a case and review of the literature. Med Mol Morphol. 2005; 38(4):256-61. DOI: 10.1007/s00795-005-0293-4. View

11.

Kubota T, Ohyama S, Hiki N, Nunobe S, Yamamoto N, Yamaguchi T . Endocrine carcinoma of the stomach: clinicopathological analysis of 27 surgically treated cases in a single institute. Gastric Cancer. 2012; 15(3):323-30. DOI: 10.1007/s10120-011-0122-5. View

12.

Adler A, Cestero C, Lewis 3rd E, Roberts I, Castillo E . Composite adenocarcinoma and carcinoid gastric tumor in chronic atrophic gastritis and pernicious anemia. Case Rep Gastroenterol. 2011; 5(1):232-8. PMC: 3088755. DOI: 10.1159/000327986. View

13.

Veits L, Lang-Schwarz C, Volkholz H, Falkeis C, Vieth M, Schulz H . Mixed adenoneuroendocrine carcinoma (MANEC) of the esophagogastric junction predominantly consisting of poorly differentiated neuroendocrine carcinoma. Endoscopy. 2013; 45 Suppl 2 UCTN:E16-7. DOI: 10.1055/s-0032-1326113. View

14.

Mitsutsuji M, Okamura A . [A resected case of metachronous liver metastasis from mixed adenoneuroendocrine carcinoma of the stomach]. Nihon Shokakibyo Gakkai Zasshi. 2011; 108(11):1910-5. View

15.

Matsui K, Jin X, Kitagawa M, Miwa A . Clinicopathologic features of neuroendocrine carcinomas of the stomach: appraisal of small cell and large cell variants. Arch Pathol Lab Med. 1998; 122(11):1010-7. View

16.

Ohhinata R, Iwasaki Y, Ohashi M, Iwanaga T, Takahashi K, Yamaguchi T . [A case of gastric endocrine cell carcinoma with liver metastases treated with S-1/CDDP]. Gan To Kagaku Ryoho. 2011; 37(12):2508-10. View

17.

Miguchi M, Iseki M, Shimatani K . Advanced gastric neuroendocrine carcinoma with an adenocarcinoma component. Case Rep Gastroenterol. 2012; 6(1):52-7. PMC: 3304076. DOI: 10.1159/000336320. View

18.

Li A, Chia-Heng Li A, Hsu C, Li W, Hsu H, Chen J . Small cell carcinomas in gastrointestinal tract: immunohistochemical and clinicopathological features. J Clin Pathol. 2010; 63(7):620-5. DOI: 10.1136/jcp.2010.077024. View

19.

Nakai M, Kawasaki H, Wajima N, Kimura A, Nakayama Y, Muroya T . [A case of mixed adenoneuroendocrine carcinoma of the esophagogastric junction treated with neoadjuvant chemotherapy]. Gan To Kagaku Ryoho. 2014; 40(12):2301-3. View

20.

Levi Sandri G, Carboni F, Valle M, Visca P, Garofalo A . Mixed adenoneuroendocrine gastric carcinoma: a case report and review of the literature. J Gastric Cancer. 2014; 14(1):63-6. PMC: 3996252. DOI: 10.5230/jgc.2014.14.1.63. View