Clinical Characteristics of Early Neuroendocrine Carcinoma in Stomach: A Case Report and Review of Literature

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2019 Jul 27

PMID 31348317

Citations 3

Authors

Xiaolong Zhu

Haiyan Jing

Takashi Yao

Affiliations

Soon will be listed here.

Abstract

Introduction: Gastric neuroendocrine carcinoma (NEC) is rare. It is considered to be aggressive and has a poor prognosis since the diagnosis is usually made at its advanced stage. However, the survival rate is increased in some early gastric NECs. This study showed a case and reviewed the clinical characteristics of early NECs in stomach.

Patient Concerns: A 38-year-old man displayed no symptoms and underwent the gastric endoscopy test for his health examination, which showed a red slightly depressed lesion 1.0 cm in size on the lesser curvature of gastric cardia. Magnifying endoscopy with narrow-band imaging (NBI) revealed a clear demarcation and an irregular mesh in vessels within the depressed area. The background mucosa was negative for atrophic gastritis and Helicobacter Pylori infection. A contrast-enhanced computed tomography (CT) scan disclosed no obvious thickening of stomach and lymphadenopathy. Blood tests and physical examination were unremarkable. He had not received any surgical treatment and denied a family history of cancer and any genetic disorders. The pathologic result of biopsy from the lesion was suspicious of superficial carcinoma. Then endoscopic submucosal dissection (ESD) was performed.

Diagnosis: Gastric NEC G3 in the early stage (T1aN0M0).

Interventions: Concerning this patient's situation, we considered the ESD as a curable treatment. And no radical surgery or adjuvant chemotherapy was arranged.

Outcomes: The patient is doing well and displays no recurrence for 11 months, who is still in follow-up.

Lessons Subsections As Per Style: The early diagnosis and effective treatment by endoscopy would contribute to improve the prognosis of gastric NECs.

Citing Articles

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