Elaborating the Role of Natural Products-induced Autophagy in Cancer Treatment: Achievements and Artifacts in the State of the Art

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Mar 31

PMID 25821829

Citations 27

Authors

Ning Wang

Yibin Feng

Affiliations

Soon will be listed here.

Abstract

Autophagy is a homeostatic process that is highly conserved across different types of mammalian cells. Autophagy is able to relieve tumor cell from nutrient and oxidative stress during the rapid expansion of cancer. Excessive and sustained autophagy may lead to cell death and tumor shrinkage. It was shown in literature that many anticancer natural compounds and extracts could initiate autophagy in tumor cells. As summarized in this review, the tumor suppressive action of natural products-induced autophagy may lead to cell senescence, provoke apoptosis-independent cell death, and complement apoptotic cell death by robust or target-specific mechanisms. In some cases, natural products-induced autophagy could protect tumor cells from apoptotic death. Technical variations in detecting autophagy affect data quality, and study focus should be made on elaborating the role of autophagy in deciding cell fate. In vivo study monitoring of autophagy in cancer treatment is expected to be the future direction. The clinical-relevant action of autophagy-inducing natural products should be highlighted in future study. As natural products are an important resource in discovery of lead compound of anticancer drug, study on the role of autophagy in tumor suppressive effect of natural products continues to be necessary and emerging.

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References

De A, De A, Papasian C, Hentges S, Banerjee S, Haque I . Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors. PLoS One. 2013; 8(8):e72748. PMC: 3794841. DOI: 10.1371/journal.pone.0072748. View

Chen J, Chang C, Wang J, Wen C, Tseng L, Chang W . In Vitro and In Vivo Effects of Jia-Wei-Xiao-Yao-San in Human Breast Cancer MCF-7 Cells Treated With Tamoxifen. Integr Cancer Ther. 2014; 13(3):226-39. DOI: 10.1177/1534735414520970. View

Chen M, Du Y, Qui M, Wang M, Chen K, Huang Z . Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway. Oncol Rep. 2012; 29(2):430-6. PMC: 3583607. DOI: 10.3892/or.2012.2131. View

Xavier C, Lima C, Pedro D, Wilson J, Kristiansen K, Pereira-Wilson C . Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells. J Nutr Biochem. 2012; 24(4):706-12. DOI: 10.1016/j.jnutbio.2012.04.004. View

Zhou J, Hu H, Long J, Wan F, Li L, Zhang S . Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway. Anticancer Drugs. 2013; 24(9):928-36. DOI: 10.1097/CAD.0b013e328364e8d3. View

Shen S, Zhang Y, Wang Z, Liu R, Gong X . Bufalin induces the interplay between apoptosis and autophagy in glioma cells through endoplasmic reticulum stress. Int J Biol Sci. 2014; 10(2):212-24. PMC: 3927133. DOI: 10.7150/ijbs.8056. View

Kuo Y, Su Y, Tseng Y, Wang S, Wang H, Chueh P . Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. Free Radic Biol Med. 2010; 49(2):214-26. DOI: 10.1016/j.freeradbiomed.2010.04.005. View

Wang Z, Zhang J, Wang Y, Xing R, Yi C, Zhu H . Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases. Carcinogenesis. 2012; 34(1):128-38. DOI: 10.1093/carcin/bgs295. View

Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal B, Kondo Y . Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol. 2007; 72(1):29-39. DOI: 10.1124/mol.106.033167. View

10.

Denton D, Nicolson S, Kumar S . Cell death by autophagy: facts and apparent artefacts. Cell Death Differ. 2011; 19(1):87-95. PMC: 3252836. DOI: 10.1038/cdd.2011.146. View

11.

Maskey D, Yousefi S, Schmid I, Zlobec I, Perren A, Friis R . ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy. Nat Commun. 2013; 4:2130. PMC: 3753548. DOI: 10.1038/ncomms3130. View

12.

Qiu W, Su M, Xie F, Ai J, Ren Y, Zhang J . Tetrandrine blocks autophagic flux and induces apoptosis via energetic impairment in cancer cells. Cell Death Dis. 2014; 5:e1123. PMC: 3973245. DOI: 10.1038/cddis.2014.84. View

13.

Tsujimoto Y, Shimizu S . Another way to die: autophagic programmed cell death. Cell Death Differ. 2005; 12 Suppl 2:1528-34. DOI: 10.1038/sj.cdd.4401777. View

14.

Amaravadi R, Thompson C . The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res. 2007; 13(24):7271-9. DOI: 10.1158/1078-0432.CCR-07-1595. View

15.

Yan G, Lanza-Jacoby S, Wang C . Nexrutine inhibits survival and induces G1 cell cycle arrest, which is associated with apoptosis or autophagy depending on the breast cancer cell line. Nutr Cancer. 2013; 66(3):506-16. DOI: 10.1080/01635581.2013.780627. View

16.

Man K, Ng K, Xu A, Cheng Q, Lo C, Xiao J . Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling. Clin Cancer Res. 2010; 16(3):967-77. DOI: 10.1158/1078-0432.CCR-09-1487. View

17.

Rogov V, Dotsch V, Johansen T, Kirkin V . Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. Mol Cell. 2014; 53(2):167-78. DOI: 10.1016/j.molcel.2013.12.014. View

18.

Miao Q, Bi L, Li X, Miao S, Zhang J, Zhang S . Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells: roles of apoptosis and autophagy. Int J Mol Sci. 2013; 14(1):1370-82. PMC: 3565325. DOI: 10.3390/ijms14011370. View

19.

Filippi-Chiela E, Villodre E, Zamin L, Lenz G . Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells. PLoS One. 2011; 6(6):e20849. PMC: 3113895. DOI: 10.1371/journal.pone.0020849. View

20.

Lu C, Wang W, Jia Y, Liu X, Tong Z, Li B . Inhibition of AMPK/autophagy potentiates parthenolide-induced apoptosis in human breast cancer cells. J Cell Biochem. 2014; 115(8):1458-66. DOI: 10.1002/jcb.24808. View