Enriched Environment Reduces Glioma Growth Through Immune and Non-immune Mechanisms in Mice

Overview

Journal Nat Commun

Specialty Biology

Date 2015 Mar 31

PMID 25818172

Citations 78

Authors

Stefano Garofalo

Giuseppina DAlessandro

Giuseppina Chece

Frederic Brau

Laura Maggi

Alessandro Rosa

Alessandra Porzia

Fabrizio Mainiero

Vincenzo Esposito

Clotilde Lauro

Giorgia Benigni

Giovanni Bernardini

Angela Santoni

Cristina Limatola

Affiliations

Soon will be listed here.

Abstract

Mice exposed to standard (SE) or enriched environment (EE) were transplanted with murine or human glioma cells and differences in tumour development were evaluated. We report that EE exposure affects: (i) tumour size, increasing mice survival; (ii) glioma establishment, proliferation and invasion; (iii) microglia/macrophage (M/Mφ) activation; (iv) natural killer (NK) cell infiltration and activation; and (v) cerebral levels of IL-15 and BDNF. Direct infusion of IL-15 or BDNF in the brain of mice transplanted with glioma significantly reduces tumour growth. We demonstrate that brain infusion of IL-15 increases the frequency of NK cell infiltrating the tumour and that NK cell depletion reduces the efficacy of EE and IL-15 on tumour size and of EE on mice survival. BDNF infusion reduces M/Mφ infiltration and CD68 immunoreactivity in tumour mass and reduces glioma migration inhibiting the small G protein RhoA through the truncated TrkB.T1 receptor. These results suggest alternative approaches for glioma treatment.

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