Notch Signaling: a Hero or Villain in the War Against Cancer?

Overview

Journal Transl Lung Cancer Res

Date 2015 Mar 26

PMID 25806268

Citations 4

Authors

Shireen Chikara

Katie M Reindl

Affiliations

Soon will be listed here.

Abstract

The Notch signal transduction pathway regulates cell fate decisions throughout embryonic development. The mechanisms through which Notch signaling maintains cellular integrity are well understood. However, Notch signaling is more complex than previously thought as Notch is also involved in cancer where it functions as both an oncogene and tumor suppressor depending on the cellular context. Aberrant activation of oncogenic Notch is found in various cancers prompting the search for therapeutic agents to attenuate constitutively active Notch. However, there is also substantial evidence that Notch signaling suppresses tumor growth and progression, suggesting that Notch activators might be of therapeutic benefit in other cancers. This editorial describes the dual role of Notch signaling observed within and across multiple cancers. We highlight a study in non-small cell lung cancer cells (NSCLC) revealing a tumor suppressive role for endothelial cell Dll4-activated Notch1 and the underlying molecular mechanism involving suppression of PI3K signaling.

Citing Articles

functional and tumor suppressor role of hypothetical protein PCNXL2 with regulation of the Notch signaling pathway.

Naveed M, Imran K, Mushtaq A, Mumtaz A, Janjua H, Khalid N RSC Adv. 2022; 8(38):21414-21430.

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Fate of hematopoietic stem cells determined by Notch1 signaling (Review).

Ge Y, Wang J, Zhang H, Li J, Ye M, Jin X Exp Ther Med. 2022; 23(2):170.

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Updates on the Role of Molecular Alterations and NOTCH Signalling in the Development of Neuroendocrine Neoplasms.

von Arx C, Capozzi M, Lopez-Jimenez E, Ottaiano A, Tatangelo F, Di Mauro A J Clin Med. 2019; 8(9).

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Notch Signaling in Neuroendocrine Tumors.

Crabtree J, Singleton C, Miele L Front Oncol. 2016; 6:94.

PMID: 27148486 PMC: 4830836. DOI: 10.3389/fonc.2016.00094.

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