Lessons from the Analysis of Nonhuman Primates for Understanding Human Aging and Neurodegenerative Diseases

Overview

Journal Front Neurosci

Date 2015 Mar 20

PMID 25788873

Citations 40

Authors

Jean-Michel Verdier

Isabelle Acquatella

Corinne Lautier

Gina Devau

Stephanie Trouche

Christelle Lasbleiz

Nadine Mestre-Frances

Affiliations

Soon will be listed here.

Abstract

Animal models are necessary tools for solving the most serious challenges facing medical research. In aging and neurodegenerative disease studies, rodents occupy a place of choice. However, the most challenging questions about longevity, the complexity and functioning of brain networks or social intelligence can almost only be investigated in nonhuman primates. Beside the fact that their brain structure is much closer to that of humans, they develop highly complex cognitive strategies and they are visually-oriented like humans. For these reasons, they deserve consideration, although their management and care are more complicated and the related costs much higher. Despite these caveats, considerable scientific advances have been possible using nonhuman primates. This review concisely summarizes their role in the study of aging and of the mechanisms involved in neurodegenerative disorders associated mainly with cognitive dysfunctions (Alzheimer's and prion diseases) or motor deficits (Parkinson's and related diseases).

Citing Articles

An Overview of Anesthetic Procedures for Ferret (Mustela putorius furo) Preclinical Brain MRI: A Call for Standardization.

Celdran-Bonafonte D, OConnell K, Dieckhaus L, Mocarski E, Adras N, Hutchinson E J Am Assoc Lab Anim Sci. 2025; 64(1):16-28.

PMID: 40035279 PMC: 11808380. DOI: 10.30802/AALAS-JAALAS-24-086.

Contributions and future potential of animal models for geroscience research on sensory systems.

Fernandes A, Poirier A, Veilleux C, Melin A Geroscience. 2024; 47(1):61-83.

PMID: 39312151 PMC: 11872837. DOI: 10.1007/s11357-024-01327-5.

Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates.

Greenberg E, Voorbach M, Smith A, Reuter D, Zhuang Y, Wang J Heliyon. 2024; 10(16):e36483.

PMID: 39253182 PMC: 11382177. DOI: 10.1016/j.heliyon.2024.e36483.

The multilevel extensive diversity across the cynomolgus macaque captured by ultra-deep adaptive immune receptor repertoire sequencing.

Zhu Y, Tang H, Xie W, Chen S, Zeng H, Lan C Sci Adv. 2024; 10(4):eadj5640.

PMID: 38266093 PMC: 10807814. DOI: 10.1126/sciadv.adj5640.

Exploring strategy differences between humans and monkeys with recurrent neural networks.

Tsuda B, Richmond B, Sejnowski T PLoS Comput Biol. 2023; 19(11):e1011618.

PMID: 37983250 PMC: 10695363. DOI: 10.1371/journal.pcbi.1011618.

References

Herzog C, Sales N, Etchegaray N, Charbonnier A, Freire S, Dormont D . Tissue distribution of bovine spongiform encephalopathy agent in primates after intravenous or oral infection. Lancet. 2004; 363(9407):422-8. DOI: 10.1016/S0140-6736(04)15487-1. View

Darusman H, Pandelaki J, Mulyadi R, Sajuthi D, Putri I, Kalliokoski O . Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid. In Vivo. 2014; 28(2):173-84. View

Joseph-Mathurin N, Dorieux O, Trouche S, Boutajangout A, Kraska A, Fontes P . Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds. Neurobiol Aging. 2013; 34(11):2613-22. PMC: 4107237. DOI: 10.1016/j.neurobiolaging.2013.05.013. View

Perret M . Change in photoperiodic cycle affects life span in a prosimian primate (Microcebus murinus). J Biol Rhythms. 1997; 12(2):136-45. DOI: 10.1177/074873049701200205. View

Abildgaard C, Harrison J, Johnson C . Comparative study of blood coagulation in nonhuman primates. J Appl Physiol. 1971; 30(3):400-5. DOI: 10.1152/jappl.1971.30.3.400. View

Abdel Rassoul R, Alves S, Pantesco V, De Vos J, Michel B, Perret M . Distinct transcriptome expression of the temporal cortex of the primate Microcebus murinus during brain aging versus Alzheimer's disease-like pathology. PLoS One. 2010; 5(9). PMC: 2940844. DOI: 10.1371/journal.pone.0012770. View

Fischer K, Austad S . The development of small primate models for aging research. ILAR J. 2011; 52(1):78-88. PMC: 4422641. DOI: 10.1093/ilar.52.1.78. View

Krasemann S, Sikorska B, Liberski P, Glatzel M . Non-human primates in prion research. Folia Neuropathol. 2012; 50(1):57-67. View

Trouche S, Asuni A, Rouland S, Wisniewski T, Frangione B, Verdier J . Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives. Vaccine. 2008; 27(7):957-64. PMC: 2713060. DOI: 10.1016/j.vaccine.2008.12.012. View

10.

Torrent J, Soukkarieh C, Lenaers G, Arndt C, Forster V, Picaud S . Microcebus murinus retina: a new model to assess prion-related neurotoxicity in primates. Neurobiol Dis. 2010; 39(2):211-20. DOI: 10.1016/j.nbd.2010.04.010. View

11.

Nader M, Banks M . Environmental modulation of drug taking: Nonhuman primate models of cocaine abuse and PET neuroimaging. Neuropharmacology. 2013; 76 Pt B:510-7. PMC: 3812308. DOI: 10.1016/j.neuropharm.2013.05.044. View

12.

Mestre-Frances N, Nicot S, Rouland S, Biacabe A, Quadrio I, Perret-Liaudet A . Oral transmission of L-type bovine spongiform encephalopathy in primate model. Emerg Infect Dis. 2012; 18(1):142-5. PMC: 3310119. DOI: 10.3201/eid1801.111092. View

13.

Orgogozo J, Gilman S, Dartigues J, Laurent B, Puel M, Kirby L . Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology. 2003; 61(1):46-54. DOI: 10.1212/01.wnl.0000073623.84147.a8. View

14.

Uno H, Walker L . The age of biosenescence and the incidence of cerebral beta-amyloidosis in aged captive rhesus monkeys. Ann N Y Acad Sci. 1993; 695:232-5. DOI: 10.1111/j.1749-6632.1993.tb23058.x. View

15.

Lemere C, Beierschmitt A, Iglesias M, Spooner E, Bloom J, Leverone J . Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am J Pathol. 2004; 165(1):283-97. PMC: 1618542. DOI: 10.1016/s0002-9440(10)63296-8. View

16.

Sigurdsson E, Scholtzova H, Mehta P, Frangione B, Wisniewski T . Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am J Pathol. 2001; 159(2):439-47. PMC: 1850561. DOI: 10.1016/s0002-9440(10)61715-4. View

17.

Capitanio J, Emborg M . Contributions of non-human primates to neuroscience research. Lancet. 2008; 371(9618):1126-35. DOI: 10.1016/S0140-6736(08)60489-4. View

18.

Languille S, Blanc S, Blin O, Canale C, Dal-Pan A, Devau G . The grey mouse lemur: a non-human primate model for ageing studies. Ageing Res Rev. 2011; 11(1):150-62. DOI: 10.1016/j.arr.2011.07.001. View

19.

Bons N, Jallageas V, Silhol S, Mestre-Frances N, PETTER A, Delacourte A . Immunocytochemical characterization of Tau proteins during cerebral aging of the lemurian primate Microcebus murinus. C R Acad Sci III. 1995; 318(7):741-7. View

20.

Schoenemann P, Sheehan M, Glotzer L . Prefrontal white matter volume is disproportionately larger in humans than in other primates. Nat Neurosci. 2005; 8(2):242-52. DOI: 10.1038/nn1394. View