Zebrafish Mutants of the Neuromuscular Junction: Swimming in the Gene Pool

Overview

Journal J Physiol Sci

Specialty Physiology

Date 2015 Mar 19

PMID 25782439

Citations 6

Authors

Eriko Daikoku

Masahisa Saito

Fumihito Ono

Affiliations

Soon will be listed here.

Abstract

This review provides an overview of zebrafish mutants with dysfunctional acetylcholine receptors or related proteins at the neuromuscular junction (NMJ). The NMJ, which has served as the classical model of the chemical synapse, uses acetylcholine as the neurotransmitter, and mutations of proteins involved in the signaling cascade lead to a variety of behavioral phenotypes. Mutants isolated after random chemical mutagenesis screening are summarized, and advances in the field resulting from these mutants are discussed.

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