Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis

Overview

Journal Neurotherapeutics

Specialty Neurology

Date 2015 Mar 18

PMID 25776222

Citations 12

Authors

Stephen A Goutman

Kevin S Chen

Eva L Feldman

Affiliations

Soon will be listed here.

Abstract

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease of the motor neurons without a known cure. Based on the possibility of cellular neuroprotection and early preclinical results, stem cells have gained widespread enthusiasm as a potential treatment strategy. Preclinical models demonstrate a protective role of engrafted stem cells and provided the basis for human trials carried out using various types of stem cells, as well as a range of cell delivery methods. To date, no trial has demonstrated a clear therapeutic benefit; however, results remain encouraging and are the basis for ongoing studies. In addition, stem cell technology continues to improve, and induced pluripotent stem cells may offer additional therapeutic options in the future. Improved disease models and clinical trials will be essential in order to validate stem cells as a beneficial therapy.

Citing Articles

Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders.

Zayed M, Sultan S, Alsaab H, Yousof S, Alrefaei G, Alsubhi N Cells. 2022; 11(21).

PMID: 36359871 PMC: 9655836. DOI: 10.3390/cells11213476.

Case Report: Stem cell therapy in amyotrophic lateral sclerosis.

Hassan A, Elkins J, Hassan H F1000Res. 2022; 10:1080.

PMID: 35087666 PMC: 8762680. DOI: 10.12688/f1000research.73967.2.

PuraMatrix hydrogel enhances the expression of motor neuron progenitor marker and improves adhesion and proliferation of motor neuron-like cells.

Darvishi M, Ghasemi Hamidabadi H, Negah S, Moayeri A, Tiraihi T, Mirnajafi-Zadeh J Iran J Basic Med Sci. 2020; 23(4):431-438.

PMID: 32489557 PMC: 7239419. DOI: 10.22038/ijbms.2020.39797.9434.

Cell-based therapies for amyotrophic lateral sclerosis/motor neuron disease.

Abdul Wahid S, Law Z, Ismail N, Lai N Cochrane Database Syst Rev. 2019; 12:CD011742.

PMID: 31853962 PMC: 6920743. DOI: 10.1002/14651858.CD011742.pub3.

Uses for humanised mouse models in precision medicine for neurodegenerative disease.

Nair R, Corrochano S, Gasco S, Tibbit C, Thompson D, Maduro C Mamm Genome. 2019; 30(7-8):173-191.

PMID: 31203387 PMC: 6759662. DOI: 10.1007/s00335-019-09807-2.

References

Lu P, Blesch A, Tuszynski M . Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact?. J Neurosci Res. 2004; 77(2):174-91. DOI: 10.1002/jnr.20148. View

Chen L, Chen D, Xi H, Wang Q, Liu Y, Zhang F . Olfactory ensheathing cell neurorestorotherapy for amyotrophic lateral sclerosis patients: benefits from multiple transplantations. Cell Transplant. 2012; 21 Suppl 1:S65-77. DOI: 10.3727/096368912X633789. View

Boulis N, Federici T, Glass J, Lunn J, Sakowski S, Feldman E . Translational stem cell therapy for amyotrophic lateral sclerosis. Nat Rev Neurol. 2011; 8(3):172-6. DOI: 10.1038/nrneurol.2011.191. View

Xu L, Ryugo D, Pongstaporn T, Johe K, Koliatsos V . Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry. J Comp Neurol. 2009; 514(4):297-309. PMC: 2727711. DOI: 10.1002/cne.22022. View

Mitrecic D, Nicaise C, Gajovic S, Pochet R . Distribution, differentiation, and survival of intravenously administered neural stem cells in a rat model of amyotrophic lateral sclerosis. Cell Transplant. 2010; 19(5):537-48. DOI: 10.3727/096368910X498269. View

Solomon J, Lewis C, Ajami B, Corbel S, Rossi F, Krieger C . Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis. Glia. 2006; 53(7):744-53. DOI: 10.1002/glia.20331. View

Martinez H, Molina-Lopez J, Gonzalez-Garza M, Moreno-Cuevas J, Caro-Osorio E, Gil-Valadez A . Stem cell transplantation in amyotrophic lateral sclerosis patients: methodological approach, safety, and feasibility. Cell Transplant. 2013; 21(9):1899-907. DOI: 10.3727/096368911X582769. View

Martin L, Liu Z . Adult olfactory bulb neural precursor cell grafts provide temporary protection from motor neuron degeneration, improve motor function, and extend survival in amyotrophic lateral sclerosis mice. J Neuropathol Exp Neurol. 2007; 66(11):1002-18. DOI: 10.1097/nen.0b013e318158822b. View

Garbuzova-Davis S, Willing A, Milliken M, Saporta S, Zigova T, Cahill D . Positive effect of transplantation of hNT neurons (NTera 2/D1 cell-line) in a model of familial amyotrophic lateral sclerosis. Exp Neurol. 2002; 174(2):169-80. DOI: 10.1006/exnr.2002.7860. View

10.

Martinez H, Gonzalez-Garza M, Moreno-Cuevas J, Caro E, Gutierrez-Jimenez E, Segura J . Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients. Cytotherapy. 2009; 11(1):26-34. DOI: 10.1080/14653240802644651. View

11.

Wichterle H, Lieberam I, Porter J, Jessell T . Directed differentiation of embryonic stem cells into motor neurons. Cell. 2002; 110(3):385-97. DOI: 10.1016/s0092-8674(02)00835-8. View

12.

Miller R, Moore 2nd D, Gelinas D, Dronsky V, Mendoza M, Barohn R . Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology. 2001; 56(7):843-8. DOI: 10.1212/wnl.56.7.843. View

13.

Ramon-Cueto A, Cordero M, Avila J . Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron. 2000; 25(2):425-35. DOI: 10.1016/s0896-6273(00)80905-8. View

14.

Chestkov I, Vasilieva E, Illarioshkin S, Lagarkova M, Kiselev S . Patient-Specific Induced Pluripotent Stem Cells for SOD1-Associated Amyotrophic Lateral Sclerosis Pathogenesis Studies. Acta Naturae. 2014; 6(1):54-60. PMC: 3999466. View

15.

Woodbury D, Schwarz E, Prockop D, Black I . Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res. 2000; 61(4):364-70. DOI: 10.1002/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C. View

16.

Ringholz G, Appel S, Bradshaw M, Cooke N, Mosnik D, Schulz P . Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology. 2005; 65(4):586-90. DOI: 10.1212/01.wnl.0000172911.39167.b6. View

17.

Forostyak S, Jendelova P, Kapcalova M, Arboleda D, Sykova E . Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis. Cytotherapy. 2011; 13(9):1036-46. DOI: 10.3109/14653249.2011.592521. View

18.

Mazzini L, Mareschi K, Ferrero I, Vassallo E, Oliveri G, Nasuelli N . Stem cell treatment in Amyotrophic Lateral Sclerosis. J Neurol Sci. 2007; 265(1-2):78-83. DOI: 10.1016/j.jns.2007.05.016. View

19.

Chan-Il C, Young-Don L, Heejaung K, Kim S, Suh-Kim H, Kim S . Neural induction with neurogenin 1 enhances the therapeutic potential of mesenchymal stem cells in an amyotrophic lateral sclerosis mouse model. Cell Transplant. 2012; 22(5):855-70. DOI: 10.3727/096368912X637019. View

20.

Lunn J, Sakowski S, Federici T, Glass J, Boulis N, Feldman E . Stem cell technology for the study and treatment of motor neuron diseases. Regen Med. 2011; 6(2):201-13. PMC: 3154698. DOI: 10.2217/rme.11.6. View