Unilateral Acute Maculopathy Associated with Adult Onset Hand, Foot and Mouth Disease: Case Report and Review of Literature

Overview

Journal J Ophthalmic Inflamm Infect

Publisher Springer

Specialty Ophthalmology

Date 2015 Mar 17

PMID 25774239

Citations 10

Authors

Rupesh Agrawal

Kanchan Bhan

Kam Balaggan

Richard Wj Lee

Carlos E Pavesio

Peter Kf Addison

Affiliations

Soon will be listed here.

Abstract

Background: Acute maculopathy is a rare condition of unknown aetiology and Coxsackie virus is known to be associated with this macular chorioretinitis.

Findings: We report a case of acute unilateral maculopathy in a 35-year-old woman with concurrent hand foot and mouth disease. Furthermore, we display multimodal imaging (colour fundus photographs, autofluorescence, spectral domain ocular coherence tomography, fluorescein angiography and indocyanine green angiography) charting the course of the disease. The source of the virus was thought to be the patient's child. Empirical treatment with oral corticosteroids was commenced and the inflammation resolved, leaving a residual macular scar.

Conclusions: We present this case combined with the review of literature of adult onset Coxsackie-virus-associated retinitis. This case reiterates the fact that Coxsackie virus is an uncommon but important consideration in the differential diagnosis of chorioretinitis and posterior uveitis with atypical retinopathy.

Citing Articles

A case of acute idiopathic maculopathy in both eyes with peripheral vascular occlusion.

Jia Y, Zhang H, Kang L, Jiang L, Chen C BMC Ophthalmol. 2024; 24(1):498.

PMID: 39543553 PMC: 11566518. DOI: 10.1186/s12886-024-03757-3.

The Relevance of Bacillary Layer Detachment and Choroidal flow Insufficiency in Unilateral Acute Idiopathic Maculopathy Associated with Hand, Foot, and Mouth Disease: A Case Report.

Thakur R, Guleser U, Kesim C, Kapran Z, Tugal-Tutkun I, Hasanreisoglu M Beyoglu Eye J. 2024; 9(3):165-171.

PMID: 39239626 PMC: 11372403. DOI: 10.14744/bej.2024.76093.

Hand, Foot, and Mouth Disease: A Narrative Review.

Leung A, Lam J, Barankin B, Leong K, Hon K Recent Adv Inflamm Allergy Drug Discov. 2022; 16(2):77-95.

PMID: 36284392 DOI: 10.2174/1570180820666221024095837.

Multimodal Imaging of Unilateral Acute Maculopathy Associated with Hand, Foot, and Mouth Disease: A Case Series.

Anjou M, Fajnkuchen F, Nabholz N, Nghiem-Buffet S, Mrejen S, Giocanti-Auregan A Case Rep Ophthalmol. 2022; 13(2):617-625.

PMID: 36160496 PMC: 9459532. DOI: 10.1159/000525940.

Acute unilateral maculopathy associated with adult onset of hand, foot and mouth disease: a case report.

Reich M, Cakir B, Cvetkoski S, Lang S, Stahl A, Ness T BMC Ophthalmol. 2019; 19(1):104.

PMID: 31064339 PMC: 6505311. DOI: 10.1186/s12886-019-1111-4.

References

Jung C, Payne J, Bergstrom C, Cribbs B, Yan J, Hubbard 3rd G . Multimodality diagnostic imaging in unilateral acute idiopathic maculopathy. Arch Ophthalmol. 2012; 130(1):50-6. PMC: 4116109. DOI: 10.1001/archophthalmol.2011.359. View

Haamann P, Kessel L, Larsen M . Monofocal outer retinitis associated with hand, foot, and mouth disease caused by coxsackievirus. Am J Ophthalmol. 2000; 129(4):552-3. DOI: 10.1016/s0002-9394(99)00440-7. View

Hirakata K, Oshima T, Azuma N . Chorioretinitis induced by coxsackievirus B4 infection. Am J Ophthalmol. 1990; 109(2):225-7. DOI: 10.1016/s0002-9394(14)75993-8. View

Huemer H, Larcher C, Kirchebner W, Klingenschmid J, Gottinger W, Irschick E . Susceptibility of human retinal pigment epithelial cells to different viruses. Graefes Arch Clin Exp Ophthalmol. 1996; 234(3):177-85. PMC: 7088335. DOI: 10.1007/BF00462030. View

Forster W, Bialasiewicz A, Busse H . Coxsackievirus B3-associated panuveitis. Br J Ophthalmol. 1993; 77(3):182-3. PMC: 504469. DOI: 10.1136/bjo.77.3.182. View

Kaminska K, Martinetti G, Lucchini R, Kaya G, Mainetti C . Coxsackievirus A6 and Hand, Foot and Mouth Disease: Three Case Reports of Familial Child-to-Immunocompetent Adult Transmission and a Literature Review. Case Rep Dermatol. 2013; 5(2):203-9. PMC: 3764954. DOI: 10.1159/000354533. View

Kadrmas E, Buzney S . Coxsackievirus B4 as a cause of adult chorioretinitis. Am J Ophthalmol. 1999; 127(3):347-9. DOI: 10.1016/s0002-9394(98)00322-5. View

Xing W, Liao Q, Viboud C, Zhang J, Sun J, Wu J . Hand, foot, and mouth disease in China, 2008-12: an epidemiological study. Lancet Infect Dis. 2014; 14(4):308-318. PMC: 4035015. DOI: 10.1016/S1473-3099(13)70342-6. View

Newman H, Gooding C . Viral ocular manifestations: a broad overview. Rev Med Virol. 2013; 23(5):281-94. DOI: 10.1002/rmv.1749. View

10.

Demirel S, Ozmert E, Batioglu F . Unilateral acute maculopathy related to hand, foot, and mouth disease: OCT and fluorescein angiography findings of a very rare disease. Eur J Ophthalmol. 2013; 24(1):131-3. DOI: 10.5301/ejo.5000288. View

11.

Takeuchi M, Sakai J, Usui M . Coxsackievirus B4 associated uveoretinitis in an adult. Br J Ophthalmol. 2003; 87(4):501-2. PMC: 1771584. DOI: 10.1136/bjo.87.4.501. View

12.

Vaz-Pereira S, Macedo M, De Salvo G, Pal B . Multimodal imaging of exudative maculopathy associated with hand-foot-mouth disease. Ophthalmic Surg Lasers Imaging Retina. 2014; 45 Online:e14-7. DOI: 10.3928/23258160-20140331-01. View

13.

Sepah Y, Akhtar A, Sadiq M, Hafeez Y, Nasir H, Perez B . Fundus autofluorescence imaging: Fundamentals and clinical relevance. Saudi J Ophthalmol. 2014; 28(2):111-6. PMC: 4023118. DOI: 10.1016/j.sjopt.2014.03.008. View