A Literature Review and Case Report of Hand, Foot and Mouth Disease in an Immunocompetent Adult

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2016 Mar 16

PMID 26975350

Citations 18

Authors

Carlos Omana-Cepeda

Andrea Martinez-Valverde

Maria del Mar Sabater-Recolons

Enric Jane-Salas

Antonio Mari-Roig

Jose Lopez-Lopez

Affiliations

Soon will be listed here.

Abstract

Background: To report an uncommon case of hand, foot and mouth disease, (HFMD) in an immunocompetent adult; a highly infectious disease, characterized by the appearance of vesicles on the mouth, hands and feet, associated with coxsackieviruses and enteroviruses; including a literature review.

Case Report: A 23 year Caucasian male with no medical or surgical history, no allergies, was not taking any medication and smoked ten cigarettes a day, suffering from discomfort in the oral cavity; itching, burning and pain when swallowing associated with small erythematous lesions located on the hard palate, and small ulcers in tonsillar pillars and right buccal mucosa. Mild fever of 37.8 °C and general malaise. The patient reported he had had contact with a child diagnosed with HFMD. From his background and symptoms, the patient was diagnosed with HFMD. Following symptomatic treatment, the symptoms remitted in 7 days.

Methods: A literature review in MEDLINE (PubMed). The inclusion criteria were for studies on humans over the last 5 years, using the keywords HFMD.

Results: We found 925 articles, which were subsequently reduced to 52 documents after applying the inclusion criteria. Maculopapular lesions were found on hands and feet.

Conclusions: Dentists may have a key role diagnosing the disease. A surveillance system to predict future outbreaks, encourage early diagnosis, put appropriate public health measures in place and research vaccine development is vitally important in order to control the disease.

Citing Articles

Hand, foot and mouth disease (HFMD): A case report.

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Bee Venom and Its Two Main Components-Melittin and Phospholipase A2-As Promising Antiviral Drug Candidates.

Yaacoub C, Wehbe R, Roufayel R, Fajloun Z, Coutard B Pathogens. 2023; 12(11).

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Tomato flu outbreak in India: a need for precautionary measures in dental treatment.

Sekaran S, Ganapathy D Int J Surg. 2023; 109(3):511-512.

PMID: 36906748 PMC: 10389220. DOI: 10.1097/JS9.0000000000000049.

Hand, Foot, and Mouth Disease: A Narrative Review.

Leung A, Lam J, Barankin B, Leong K, Hon K Recent Adv Inflamm Allergy Drug Discov. 2022; 16(2):77-95.

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The emergence of tomato flu: Another pandemic in making?.

Kundu M, Ghosh S, Das S Ann Med Surg (Lond). 2022; 81:104523.

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References

Osterback R, Vuorinen T, Linna M, Susi P, Hyypia T, Waris M . Coxsackievirus A6 and hand, foot, and mouth disease, Finland. Emerg Infect Dis. 2009; 15(9):1485-8. PMC: 2819858. DOI: 10.3201/eid1509.090438. View

Rabenau H, Richter M, Doerr H . Hand, foot and mouth disease: seroprevalence of Coxsackie A16 and Enterovirus 71 in Germany. Med Microbiol Immunol. 2009; 199(1):45-51. DOI: 10.1007/s00430-009-0133-6. View

Zeng M, Li Y, Wang X, Lu G, Shen H, Yu H . Epidemiology of hand, foot, and mouth disease in children in Shanghai 2007-2010. Epidemiol Infect. 2011; 140(6):1122-30. DOI: 10.1017/S0950268811001622. View

Akiyama K, Imazeki R, Yoshii F, Koide T, Muto J . An adult case of hand, foot, and mouth disease caused by enterovirus 71 accompanied by opsoclonus myoclonica. Tokai J Exp Clin Med. 2011; 33(4):143-5. View

Wu Y, Shang S, Chen Z, Yang Z . [Analysis of the epidemic characteristics of the etiological agents in children with hand, foot and mouth disease and its clinical significance]. Zhonghua Er Ke Za Zhi. 2010; 48(7):535-9. View

Blomqvist S, Klemola P, Kaijalainen S, Paananen A, Simonen M, Vuorinen T . Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland. J Clin Virol. 2010; 48(1):49-54. DOI: 10.1016/j.jcv.2010.02.002. View

Yu N, Guo M, He S, Pan Y, Chen X, Ding X . Evaluation of human enterovirus 71 and coxsackievirus A16 specific immunoglobulin M antibodies for diagnosis of hand-foot-and-mouth disease. Virol J. 2012; 9:12. PMC: 3296593. DOI: 10.1186/1743-422X-9-12. View

Russo D, Luchs A, Machado B, Carmona R, Timenetsky M . Echovirus 4 associated to hand, foot and mouth disease. Rev Inst Med Trop Sao Paulo. 2006; 48(4):197-9. DOI: 10.1590/s0036-46652006000400004. View

Wang J, Guo Y, Christakos G, Yang W, Liao Y, Li Z . Hand, foot and mouth disease: spatiotemporal transmission and climate. Int J Health Geogr. 2011; 10:25. PMC: 3079592. DOI: 10.1186/1476-072X-10-25. View

10.

Ooi M, Wong S, Mohan A, Podin Y, Perera D, Clear D . Identification and validation of clinical predictors for the risk of neurological involvement in children with hand, foot, and mouth disease in Sarawak. BMC Infect Dis. 2009; 9:3. PMC: 2637878. DOI: 10.1186/1471-2334-9-3. View

11.

Yang F, Zhang T, Hu Y, Wang X, Du J, Li Y . Survey of enterovirus infections from hand, foot and mouth disease outbreak in China, 2009. Virol J. 2011; 8:508. PMC: 3227625. DOI: 10.1186/1743-422X-8-508. View

12.

Suzuki Y, Taya K, Nakashima K, Ohyama T, Kobayashi J, Ohkusa Y . Risk factors for severe hand foot and mouth disease. Pediatr Int. 2009; 52(2):203-7. DOI: 10.1111/j.1442-200X.2009.02937.x. View

13.

Na S, Son Y, Lee H, Baek J, Roh J, Lee J . A Case of Varicella Combined with Hand-foot-mouth Disease in a Healthy Child. Ann Dermatol. 2010; 21(1):98-101. PMC: 2883384. DOI: 10.5021/ad.2009.21.1.98. View

14.

Sarma N, Sarkar A, Mukherjee A, Ghosh A, Dhar S, Malakar R . Epidemic of hand, foot and mouth disease in West Bengal, India in August, 2007: a multicentric study. Indian J Dermatol. 2010; 54(1):26-30. PMC: 2800866. DOI: 10.4103/0019-5154.48982. View

15.

Yamayoshi S, Fujii K, Koike S . Scavenger receptor b2 as a receptor for hand, foot, and mouth disease and severe neurological diseases. Front Microbiol. 2012; 3:32. PMC: 3277273. DOI: 10.3389/fmicb.2012.00032. View

16.

Shin J, Oh S, Lee J . A Case of Hand-foot-mouth Disease in an Immunocompetent Adult. Ann Dermatol. 2010; 22(2):216-8. PMC: 2883431. DOI: 10.5021/ad.2010.22.2.216. View

17.

Guimbao J, Rodrigo P, Alberto M, Omenaca M . Onychomadesis outbreak linked to hand, foot, and mouth disease, Spain, July 2008. Euro Surveill. 2010; 15(37). View

18.

Chang L, Chang I, Chen W, Huang Y, Chen G, Shih S . HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics. 2008; 122(6):1271-6. DOI: 10.1542/peds.2007-3735. View

19.

Tian H, Yang Q, Liang J, Dong S, Liu Z, Wang L . Clinical features and management outcomes of severe hand, foot and mouth disease. Med Princ Pract. 2011; 21(4):355-9. DOI: 10.1159/000334619. View

20.

Zhang X, Yan H, Huang C, Tan Y, Ma D, Zhang H . [The etiology and clinical manifestations of 70 patients with hand-foot-mouth disease]. Zhonghua Yu Fang Yi Xue Za Zhi. 2010; 43(10):872-4. View