FGF22 Signaling Regulates Synapse Formation During Post-injury Remodeling of the Spinal Cord

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2015 Mar 14

PMID 25766255

Citations 27

Authors

Anne Jacobi

Kristina Loy

Anja M Schmalz

Mikael Hellsten

Hisashi Umemori

Martin Kerschensteiner

Florence M Bareyre

Affiliations

Soon will be listed here.

Abstract

The remodeling of axonal circuits after injury requires the formation of new synaptic contacts to enable functional recovery. Which molecular signals initiate such axonal and synaptic reorganisation in the adult central nervous system is currently unknown. Here, we identify FGF22 as a key regulator of circuit remodeling in the injured spinal cord. We show that FGF22 is produced by spinal relay neurons, while its main receptors FGFR1 and FGFR2 are expressed by cortical projection neurons. FGF22 deficiency or the targeted deletion of FGFR1 and FGFR2 in the hindlimb motor cortex limits the formation of new synapses between corticospinal collaterals and relay neurons, delays their molecular maturation, and impedes functional recovery in a mouse model of spinal cord injury. These results establish FGF22 as a synaptogenic mediator in the adult nervous system and a crucial regulator of synapse formation and maturation during post-injury remodeling in the spinal cord.

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