Synaptic Organizing Complexes

Overview

Journal Curr Opin Neurobiol

Specialties Biology
Neurology

Date 2010 Sep 14

PMID 20832286

Citations 166

Authors

Tabrez J Siddiqui

Ann Marie Craig

Affiliations

Soon will be listed here.

Abstract

A number of synaptogenic factors induce presynaptic or postsynaptic differentiation when presented to axons or dendrites. Many such factors participate in bidirectional trans-synaptic adhesion complexes. Axonal neurexins interacting in an isoform-specific code with multiple dendritic partners (neuroligins, LRRTMs, or Cbln-GluRδ), and axonal protein tyrosine phosphatase receptors interacting with dendritic NGL-3, nucleate local networks of high-affinity protein-protein interactions leading to aligned presynaptic and postsynaptic differentiation. Additional secreted target-derived factors such as fibroblast growth factors and glial-derived factors such as thrombospondin bind specific axonal or dendritic receptors stimulating signal transduction mechanisms to promote selective aspects of synapse development. Together with classical adhesion molecules and controlled by transcriptional cascades, these synaptogenic adhesion complexes and secreted factors organize the molecular composition and thus functional properties of central synapses.

Citing Articles

Activity-dependent synaptic competition and dendrite pruning in developing mitral cells.

Imai T Front Neural Circuits. 2025; 19:1541926.

PMID: 40034992 PMC: 11873734. DOI: 10.3389/fncir.2025.1541926.

Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula.

Wang X, Wei H, Hu Z, Jiang J, Dong X, Zhu J Theranostics. 2025; 15(5):1842-1863.

PMID: 39897557 PMC: 11780514. DOI: 10.7150/thno.104282.

Intracellular protein-lipid interactions drive presynaptic assembly prior to neurexin recruitment.

Frankel E, Tiroumalechetty A, Su Z, Henry P, Mueller B, Jorgensen E Neuron. 2025; 113(5):737-753.e6.

PMID: 39814011 PMC: 11886894. DOI: 10.1016/j.neuron.2024.12.017.

Zinc and copper effect mechanical cell adhesion properties of the amyloid precursor protein.

August A, Hartmann S, Schilling S, Muller-Renno C, Begic T, Pierik A Biol Chem. 2024; 405(11-12):701-710.

PMID: 39425975 DOI: 10.1515/hsz-2024-0054.

Neuronal LRP4 directs the development, maturation and cytoskeletal organization of Drosophila peripheral synapses.

DePew A, Bruckner J, OConnor-Giles K, Mosca T Development. 2024; 151(11).

PMID: 38738619 PMC: 11190576. DOI: 10.1242/dev.202517.

References

OBrien R, Xu D, Petralia R, Steward O, Huganir R, Worley P . Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron. 1999; 23(2):309-23. DOI: 10.1016/s0896-6273(00)80782-5. View

Knuesel I, Mastrocola M, Zuellig R, Bornhauser B, Schaub M, Fritschy J . Short communication: altered synaptic clustering of GABAA receptors in mice lacking dystrophin (mdx mice). Eur J Neurosci. 1999; 11(12):4457-62. DOI: 10.1046/j.1460-9568.1999.00887.x. View

Sara Y, Biederer T, Atasoy D, Chubykin A, Mozhayeva M, Sudhof T . Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci. 2005; 25(1):260-70. PMC: 6725191. DOI: 10.1523/JNEUROSCI.3165-04.2005. View

Hall A, LUCAS F, Salinas P . Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell. 2000; 100(5):525-35. DOI: 10.1016/s0092-8674(00)80689-3. View

Grootjans J, Reekmans G, Ceulemans H, David G . Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin. J Biol Chem. 2000; 275(26):19933-41. DOI: 10.1074/jbc.M002459200. View

Fogel A, Akins M, Krupp A, Stagi M, Stein V, Biederer T . SynCAMs organize synapses through heterophilic adhesion. J Neurosci. 2007; 27(46):12516-30. PMC: 6673342. DOI: 10.1523/JNEUROSCI.2739-07.2007. View

Stan A, Pielarski K, Brigadski T, Wittenmayer N, Fedorchenko O, Gohla A . Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation. Proc Natl Acad Sci U S A. 2010; 107(24):11116-21. PMC: 2890764. DOI: 10.1073/pnas.0914233107. View

Betancur C, Sakurai T, Buxbaum J . The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders. Trends Neurosci. 2009; 32(7):402-12. PMC: 10354373. DOI: 10.1016/j.tins.2009.04.003. View

Sia G, Beique J, Rumbaugh G, Cho R, Worley P, Huganir R . Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Neuron. 2007; 55(1):87-102. DOI: 10.1016/j.neuron.2007.06.020. View

10.

Niederkofler V, Baeriswyl T, Ott R, Stoeckli E . Nectin-like molecules/SynCAMs are required for post-crossing commissural axon guidance. Development. 2010; 137(3):427-35. DOI: 10.1242/dev.042515. View

11.

Pulido R, Serra-Pages C, Tang M, Streuli M . The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. Proc Natl Acad Sci U S A. 1995; 92(25):11686-90. PMC: 40467. DOI: 10.1073/pnas.92.25.11686. View

12.

Levinson J, El-Husseini A . Building excitatory and inhibitory synapses: balancing neuroligin partnerships. Neuron. 2005; 48(2):171-4. DOI: 10.1016/j.neuron.2005.09.017. View

13.

Salinas P, Zou Y . Wnt signaling in neural circuit assembly. Annu Rev Neurosci. 2008; 31:339-58. DOI: 10.1146/annurev.neuro.31.060407.125649. View

14.

Xu D, Hopf C, Reddy R, Cho R, Guo L, Lanahan A . Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity. Neuron. 2003; 39(3):513-28. DOI: 10.1016/s0896-6273(03)00463-x. View

15.

Seabold G, Wang P, Chang K, Wang C, Wang Y, Petralia R . The SALM family of adhesion-like molecules forms heteromeric and homomeric complexes. J Biol Chem. 2008; 283(13):8395-405. PMC: 2417176. DOI: 10.1074/jbc.M709456200. View

16.

Koch S, Ullian E . Neuronal pentraxins mediate silent synapse conversion in the developing visual system. J Neurosci. 2010; 30(15):5404-14. PMC: 2885289. DOI: 10.1523/JNEUROSCI.4893-09.2010. View

17.

Dresbach T, Neeb A, Meyer G, Gundelfinger E, Brose N . Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding. Mol Cell Neurosci. 2004; 27(3):227-35. DOI: 10.1016/j.mcn.2004.06.013. View

18.

Ko J, Zhang C, Arac D, Boucard A, Brunger A, Sudhof T . Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 2009; 28(20):3244-55. PMC: 2771087. DOI: 10.1038/emboj.2009.249. View

19.

Sugita S, Saito F, Tang J, Satz J, Campbell K, Sudhof T . A stoichiometric complex of neurexins and dystroglycan in brain. J Cell Biol. 2001; 154(2):435-45. PMC: 2150755. DOI: 10.1083/jcb.200105003. View

20.

de Wit J, Sylwestrak E, OSullivan M, Otto S, Tiglio K, Savas J . LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation. Neuron. 2010; 64(6):799-806. PMC: 2829666. DOI: 10.1016/j.neuron.2009.12.019. View