Role of Precursor MRNA Splicing in Nutrient-induced Alterations in Gene Expression and Metabolism

Overview

Journal J Nutr

Publisher Elsevier

Specialty Nutritional Sciences

Date 2015 Mar 13

PMID 25761502

Citations 15

Authors

Suhana Ravi

Rudolf J Schilder

Scot R Kimball

Affiliations

Soon will be listed here.

Abstract

Precursor mRNA (pre-mRNA) splicing is a critical step in gene expression that results in the removal of intronic sequences from immature mRNA, leading to the production of mature mRNA that can be translated into protein. Alternative pre-mRNA splicing is the process whereby alternative exons and/or introns are selectively included or excluded, generating mature mRNAs that encode proteins that may differ in function. The resulting alterations in the pattern of protein isoform expression can result in changes in protein-protein interaction, subcellular localization, and flux through metabolic pathways. Although basic mechanisms of pre-mRNA splicing of introns and exons are reasonably well characterized, how these mechanisms are regulated remains poorly understood. The goal of this review is to highlight selected recent advances in our understanding of the regulation of pre-mRNA splicing by nutrients and modulation of nutrient metabolism that result from changes in pre-mRNA splicing.

Citing Articles

Differences in alternative splicing and their potential underlying factors between animals and plants.

Du Y, Cao L, Wang S, Guo L, Tan L, Liu H J Adv Res. 2023; 64:83-98.

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U2AF1 in various neoplastic diseases and relevant targeted therapies for malignant cancers with complex mutations (Review).

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Proteomic analysis of adipose tissue revealing differentially abundant proteins in highly efficient mid-lactating dairy cows.

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Transcriptome analysis of clock disrupted cancer cells reveals differential alternative splicing of cancer hallmarks genes.

Malhan D, Basti A, Relogio A NPJ Syst Biol Appl. 2022; 8(1):17.

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Lipin 1 modulates mRNA splicing during fasting adaptation in liver.

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