» Articles » PMID: 25757560

Disentangling Calcium-driven Astrocyte Physiology

Overview
Specialty Neurology
Date 2015 Mar 12
PMID 25757560
Citations 87
Authors
Affiliations
Soon will be listed here.
Abstract

Astrocytes seem to rely on relatively sluggish and spatially blurred Ca(2+) waves to communicate with fast and point-precise neural circuits. This apparent discrepancy could, however, reflect our current inability to understand the microscopic mechanisms involved. Difficulties in detecting and interpreting astrocyte Ca(2+) signals may have led to some prominent controversies in the field. Here, we argue that a deeper understanding of astrocyte physiology requires a qualitative leap in our experimental and analytical strategies.

Citing Articles

Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome.

Dohl J, Treadwell Z, Norris C, Head E Alzheimers Dement. 2025; 21(3):e70034.

PMID: 40042516 PMC: 11881635. DOI: 10.1002/alz.70034.


A spatial threshold for astrocyte calcium surge.

Lines J, Baraibar A, Nanclares C, Martin E, Aguilar J, Kofuji P Elife. 2024; 12.

PMID: 39680037 PMC: 11649242. DOI: 10.7554/eLife.90046.


Deep-prior ODEs augment fluorescence imaging with chemical sensors.

Pham T, Boquet-Pujadas A, Mondal S, Unser M, Barbastathis G Nat Commun. 2024; 15(1):9172.

PMID: 39448575 PMC: 11502814. DOI: 10.1038/s41467-024-53232-2.


Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity.

Baraibar A, Colomer T, Moreno-Garcia A, Bernal-Chico A, Sanchez-Martin E, Utrilla C Brain Behav Immun. 2024; 121:192-210.

PMID: 39032542 PMC: 11415231. DOI: 10.1016/j.bbi.2024.07.010.


Unveiling the Hidden Impact: Hematoma Volumes Unravel Circuit Disruptions in Intracerebral Hemorrhage.

Wu Y, Deng Q, Wei R, Chen S, Ding F, Yu H Transl Stroke Res. 2024; .

PMID: 38748378 DOI: 10.1007/s12975-024-01257-6.