Plasma Fluctuation in Estradiol-17β and Bone Resorption Markers Around Parturition in Dairy Cows

Overview

Journal J Vet Med Sci

Specialty Veterinary Medicine

Date 2015 Mar 11

PMID 25755022

Citations 2

Authors

Bhuminad Devkota

Saori Sato

Kouya Sasaki

Atsushi Ueki

Takeshi Osawa

Masahiro Takahashi

Norio Yamagishi

Affiliations

Soon will be listed here.

Abstract

Blood samples were obtained sequentially from 10 dairy cows around the time of parturition to assess plasma fluctuations in estradiol-17β (E2) levels in association with those of several bone resorption markers. Plasma E2 concentration increased sharply a few days prepartum and decreased quickly after parturition. In terms of bone resorption markers, the plasma level of tartrate-resistant acid phosphatase isoform 5b (TRAP5b) rose significantly, commencing 1 week prepartum, and was maintained at this level to a few days postpartum. The plasma concentration of carboxyterminal collagen cross-links of type-I collagen (CTx) increased significantly after parturition. These observations suggest that osteoclast-mediated bone resorption was activated after parturition when plasma E2 concentrations decreased.

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References

Rosen H, Moses A, Garber J, Iloputaife I, Ross D, Lee S . Serum CTX: a new marker of bone resorption that shows treatment effect more often than other markers because of low coefficient of variability and large changes with bisphosphonate therapy. Calcif Tissue Int. 2000; 66(2):100-3. DOI: 10.1007/pl00005830. View

Liesegang A, Risteli J, Wanner M . The effects of first gestation and lactation on bone metabolism in dairy goats and milk sheep. Bone. 2005; 38(6):794-802. DOI: 10.1016/j.bone.2005.11.006. View

Allen M . Biochemical markers of bone metabolism in animals: uses and limitations. Vet Clin Pathol. 2003; 32(3):101-13. DOI: 10.1111/j.1939-165x.2003.tb00323.x. View

Holtenius K, Ekelund A . Biochemical markers of bone turnover in the dairy cow during lactation and the dry period. Res Vet Sci. 2004; 78(1):17-9. DOI: 10.1016/j.rvsc.2004.05.002. View

Rissanen J, Suominen M, Peng Z, Halleen J . Secreted tartrate-resistant acid phosphatase 5b is a Marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model. Calcif Tissue Int. 2007; 82(2):108-15. DOI: 10.1007/s00223-007-9091-4. View

Togashi M, Tsujimoto T, Yamauchi K, Deguchi Y, Hashizume K, Kizaki K . Plasma and fecal sex steroid hormone profiles during the estrous cycle in a Japanese serow (Capricornis crispus). J Reprod Dev. 2009; 55(4):412-7. DOI: 10.1262/jrd.20165. View

Yamagishi N, Takehana K, Kim D, Miura M, Hirata T, Devkota B . Fluorometric method for measuring plasma tartrate-resistant acid phosphatase isoform 5b and its application in cattle. J Vet Med Sci. 2010; 71(12):1637-42. DOI: 10.1292/jvms.001637. View

Clarke B, Khosla S . Physiology of bone loss. Radiol Clin North Am. 2010; 48(3):483-95. PMC: 2901252. DOI: 10.1016/j.rcl.2010.02.014. View

Kim D, Yamagishi N, Ueki A, Miura M, Saito F, Sato S . Changes in plasma bone metabolic markers in periparturient dairy cows. J Vet Med Sci. 2010; 72(6):773-6. DOI: 10.1292/jvms.09-0409. View

10.

Qing H, Ardeshirpour L, Divieti Pajevic P, Dusevich V, Jahn K, Kato S . Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. J Bone Miner Res. 2012; 27(5):1018-29. PMC: 3770147. DOI: 10.1002/jbmr.1567. View

11.

Khosla S, Oursler M, Monroe D . Estrogen and the skeleton. Trends Endocrinol Metab. 2012; 23(11):576-81. PMC: 3424385. DOI: 10.1016/j.tem.2012.03.008. View

12.

Devkota B, Itagaki K, Kim D, Sasaki K, Osawa T, Furuhama K . Relationship between sex hormone fluctuations and biomarkers of bone resorption in bovine plasma during the oestrous cycle. Vet J. 2012; 194(2):256-8. DOI: 10.1016/j.tvjl.2012.03.026. View

13.

Yamagishi N, Kizaki K, Sasaki K, Devkota B, Hashizume K . Microarray-based gene expression profiling of peripheral blood mononuclear cells in dairy cows with experimental hypocalcemia and milk fever. J Dairy Sci. 2013; 97(1):247-58. DOI: 10.3168/jds.2013-7049. View

14.

Goff J . Calcium and magnesium disorders. Vet Clin North Am Food Anim Pract. 2014; 30(2):359-81, vi. DOI: 10.1016/j.cvfa.2014.04.003. View

15.

Matsuo A, Togashi A, Sasaki K, Devkota B, Hirata T, Yamagishi N . Diurnal variation of plasma bone markers in Japanese black calves. J Vet Med Sci. 2014; 76(7):1029-32. PMC: 4143644. DOI: 10.1292/jvms.14-0021. View

16.

Dabev D, Struck H . Microliter determination of free hydroxyproline in blood serum. Biochem Med. 1971; 5(1):17-21. DOI: 10.1016/0006-2944(71)90070-6. View

17.

Edqvist L, Ekman L, Gustafsson B, Lindell J . Estrone and progesterone plasma levels of normal cows and cows with parturient paresis. Acta Vet Scand. 1974; 15(4):587-96. PMC: 8555162. View

18.

Sasser R, Falk D, ROSS R . Estrogen in plasma of parturient paretic and normal cows. J Dairy Sci. 1979; 62(4):551-6. DOI: 10.3168/jds.S0022-0302(79)83289-0. View

19.

Hollis B, Draper H, Burton J, Etches R . A hormonal assessment of bovine parturient paresis: evidence for a role of oestrogen. J Endocrinol. 1981; 88(2):161-71. DOI: 10.1677/joe.0.0880161. View

20.

Pyorala E, Pyorala S, Mero M, Adlercreutz H . Oestrogens and milk fever--is there a link?. Acta Vet Scand. 1992; 33(4):335-9. PMC: 8117830. View