CD28-CD80/86 and CD40-CD40L Interactions Promote Thymic Tolerance by Regulating Medullary Epithelial Cell and Thymocyte Development

Overview

Journal Crit Rev Immunol

Publisher Begell House

Specialty Allergy & Immunology

Date 2015 Mar 10

PMID 25746048

Citations 5

Authors

Joy A Williams

XuGuang Tai

Richard J Hodes

Affiliations

Soon will be listed here.

Abstract

Development and central tolerance of T lymphocytes in the thymus requires both TCR signals and collaboration with signals generated through costimulatory molecule interactions. In this review, we discuss the importance of CD28-CD80/86 and CD40-CD40L costimulatory interactions in promoting normal thymic development. This discussion includes roles in the generation of a normal thymic medulla, in the development of specific T-cells subsets, including iNKT and T regulatory cells, and in the generation of a tolerant mature T-cell repertoire. We discuss recent contributions to the understanding of CD28-CD80/86 and CD40-CD40L costimulatory interactions in thymic development, and we highlight the ways in which the many important roles mediated by these interactions collaborate to promote normal thymic development.

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References

Lee Y, Jameson S, Hogquist K . Alternative memory in the CD8 T cell lineage. Trends Immunol. 2011; 32(2):50-6. PMC: 3039080. DOI: 10.1016/j.it.2010.12.004. View

Boise L, Minn A, Noel P, June C, Accavitti M, LINDSTEN T . CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity. 1995; 3(1):87-98. DOI: 10.1016/1074-7613(95)90161-2. View

Elewaut D, Shaikh R, Hammond K, De Winter H, Leishman A, Sidobre S . NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. J Exp Med. 2003; 197(12):1623-33. PMC: 2193960. DOI: 10.1084/jem.20030141. View

Fujihara C, Williams J, Watanabe M, Jeon H, Sharrow S, Hodes R . T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction. J Immunol. 2014; 193(11):5534-44. PMC: 4239311. DOI: 10.4049/jimmunol.1401655. View

Irla M, Guerri L, Guenot J, Serge A, Lantz O, Liston A . Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla. PLoS One. 2013; 7(12):e52591. PMC: 3531460. DOI: 10.1371/journal.pone.0052591. View

Shores E, van Ewijk W, Singer A . Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment. Eur J Immunol. 1991; 21(7):1657-61. DOI: 10.1002/eji.1830210711. View

Gray D, Seach N, Ueno T, Milton M, Liston A, Lew A . Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood. 2006; 108(12):3777-85. DOI: 10.1182/blood-2006-02-004531. View

Cuss S, Green E . Abrogation of CD40-CD154 signaling impedes the homeostasis of thymic resident regulatory T cells by altering the levels of IL-2, but does not affect regulatory T cell development. J Immunol. 2012; 189(4):1717-25. PMC: 3442226. DOI: 10.4049/jimmunol.1200588. View

Shah D, Zuniga-Pflucker J . An overview of the intrathymic intricacies of T cell development. J Immunol. 2014; 192(9):4017-23. DOI: 10.4049/jimmunol.1302259. View

10.

Josefowicz S, Lu L, Rudensky A . Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012; 30:531-64. PMC: 6066374. DOI: 10.1146/annurev.immunol.25.022106.141623. View

11.

Walunas T, Sperling A, Khattri R, Thompson C, Bluestone J . CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J Immunol. 1996; 156(3):1006-13. View

12.

Gross J, Callas E, Allison J . Identification and distribution of the costimulatory receptor CD28 in the mouse. J Immunol. 1992; 149(2):380-8. View

13.

Rossi S, Kim M, Leibbrandt A, Parnell S, Jenkinson W, Glanville S . RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med. 2007; 204(6):1267-72. PMC: 2118623. DOI: 10.1084/jem.20062497. View

14.

van Ewijk W, Shores E, Singer A . Crosstalk in the mouse thymus. Immunol Today. 1994; 15(5):214-7. DOI: 10.1016/0167-5699(94)90246-1. View

15.

Pardoll D, Fowlkes B, Bluestone J, Kruisbeek A, Maloy W, Coligan J . Differential expression of two distinct T-cell receptors during thymocyte development. Nature. 1987; 326(6108):79-81. DOI: 10.1038/326079a0. View

16.

Burr J, Savage N, Messah G, Kimzey S, Shaw A, Arch R . Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL. J Immunol. 2001; 166(9):5331-5. DOI: 10.4049/jimmunol.166.9.5331. View

17.

Stamenkovic I, Clark E, Seed B . A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 1989; 8(5):1403-10. PMC: 400967. DOI: 10.1002/j.1460-2075.1989.tb03521.x. View

18.

Williams J, Sharrow S, Adams A, Hodes R . CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes. J Immunol. 2002; 168(6):2759-65. DOI: 10.4049/jimmunol.168.6.2759. View

19.

Fontenot J, Dooley J, Farr A, Rudensky A . Developmental regulation of Foxp3 expression during ontogeny. J Exp Med. 2005; 202(7):901-6. PMC: 2213175. DOI: 10.1084/jem.20050784. View

20.

Guerri L, Peguillet I, Geraldo Y, Nabti S, Premel V, Lantz O . Analysis of APC types involved in CD4 tolerance and regulatory T cell generation using reaggregated thymic organ cultures. J Immunol. 2013; 190(5):2102-10. DOI: 10.4049/jimmunol.1202883. View