Interactions Between CD44 and Hyaluronan in Leukocyte Trafficking

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2015 Mar 6

PMID 25741341

Citations 65

Authors

Braedon McDonald

Paul Kubes

Affiliations

Soon will be listed here.

Abstract

Recruitment of leukocytes from the bloodstream to inflamed tissues requires a carefully regulated cascade of binding interactions between adhesion molecules on leukocytes and endothelial cells. Adhesive interactions between CD44 and hyaluronan (HA) have been implicated in the regulation of immune cell trafficking within various tissues. In this review, the biology of CD44-HA interactions in cell trafficking is summarized, with special attention to neutrophil recruitment within the liver microcirculation. We describe the molecular mechanisms that regulate adhesion between neutrophil CD44 and endothelial HA, including recent evidence implicating serum-derived hyaluronan-associated protein as an important co-factor in the binding of HA to CD44 under flow conditions. CD44-HA-mediated neutrophil recruitment has been shown to contribute to innate immune responses to invading microbes, as well as to the pathogenesis of many inflammatory diseases, including various liver pathologies. As a result, blockade of neutrophil recruitment by targeting CD44-HA interactions has proven beneficial as an anti-inflammatory treatment strategy in a number of animal models of inflammatory diseases.

Citing Articles

ECRG4 mediates host response to cutaneous infection by regulating neutrophil recruitment and adhesion receptor expression.

Pool K, Hemmat G, Dorschner R PLoS One. 2024; 19(11):e0310810.

PMID: 39509414 PMC: 11542879. DOI: 10.1371/journal.pone.0310810.

Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations.

Ross J, Puigdelloses-Vallcorba M, Pinero G, Soni N, Thomason W, DeSisto J Immunity. 2024; 57(11):2669-2687.e6.

PMID: 39395421 PMC: 11578068. DOI: 10.1016/j.immuni.2024.09.007.

Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan-hyaladherin interactions.

Dodd R, Blundell C, Sattelle B, Enghild J, Milner C, Day A J Biol Chem. 2024; 300(9):107668.

PMID: 39128716 PMC: 11460632. DOI: 10.1016/j.jbc.2024.107668.

Small extracellular vesicles are released ex vivo from platelets into serum and from residual blood cells into stored plasma.

Malys M, Koller M, Papp K, Aigner C, Dioso D, Mucher P J Extracell Biol. 2024; 2(5):e88.

PMID: 38938276 PMC: 11080719. DOI: 10.1002/jex2.88.

Current Evidence and Perspectives of Cluster of Differentiation 44 in the Liver's Physiology and Pathology.

Han J, Lee C, Jung Y Int J Mol Sci. 2024; 25(9).

PMID: 38731968 PMC: 11084344. DOI: 10.3390/ijms25094749.

References

de la Motte C, Hascall V, Drazba J, Bandyopadhyay S, Strong S . Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid: inter-alpha-trypsin inhibitor is crucial to structure and function. Am J Pathol. 2003; 163(1):121-33. PMC: 1868154. DOI: 10.1016/s0002-9440(10)63636-x. View

Brocke S, Piercy C, Steinman L, Weissman I, Veromaa T . Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc Natl Acad Sci U S A. 1999; 96(12):6896-901. PMC: 22013. DOI: 10.1073/pnas.96.12.6896. View

Herrera M, Bussolati B, Bruno S, Morando L, Mauriello-Romanazzi G, Sanavio F . Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury. Kidney Int. 2007; 72(4):430-41. DOI: 10.1038/sj.ki.5002334. View

Milinkovic M, Antin J, Hergrueter C, Underhill C, Sackstein R . CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD. Blood. 2003; 103(2):740-2. DOI: 10.1182/blood-2003-05-1500. View

DeGrendele H, Estess P, Picker L, SIEGELMAN M . CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway. J Exp Med. 1996; 183(3):1119-30. PMC: 2192320. DOI: 10.1084/jem.183.3.1119. View

Katoh S, Ishii N, Nobumoto A, Takeshita K, Dai S, Shinonaga R . Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a murine model of allergic asthma. Am J Respir Crit Care Med. 2007; 176(1):27-35. DOI: 10.1164/rccm.200608-1243OC. View

Petrey A, de la Motte C . Hyaluronan, a crucial regulator of inflammation. Front Immunol. 2014; 5:101. PMC: 3949149. DOI: 10.3389/fimmu.2014.00101. View

Mikecz K, Brennan F, Kim J, Glant T . Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nat Med. 1995; 1(6):558-63. DOI: 10.1038/nm0695-558. View

Younossi Z, Stepanova M, Afendy M, Fang Y, Younossi Y, Mir H . Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol. 2011; 9(6):524-530.e1. DOI: 10.1016/j.cgh.2011.03.020. View

10.

Bonder C, Clark S, Norman M, Johnson P, Kubes P . Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere. Blood. 2006; 107(12):4798-806. DOI: 10.1182/blood-2005-09-3581. View

11.

Klein C, Philippe N, Le Deist F, Fraitag S, Prost C, Durandy A . Partial albinism with immunodeficiency (Griscelli syndrome). J Pediatr. 1994; 125(6 Pt 1):886-95. DOI: 10.1016/s0022-3476(05)82003-7. View

12.

Egan C, Daugherity E, Rogers A, Abi Abdallah D, Denkers E, Maurer K . CCR2 and CD44 promote inflammatory cell recruitment during fatty liver formation in a lithogenic diet fed mouse model. PLoS One. 2013; 8(6):e65247. PMC: 3676479. DOI: 10.1371/journal.pone.0065247. View

13.

Lammermann T, Bader B, Monkley S, Worbs T, Wedlich-Soldner R, Hirsch K . Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. 2008; 453(7191):51-5. DOI: 10.1038/nature06887. View

14.

McDonald B, Jenne C, Zhuo L, Kimata K, Kubes P . Kupffer cells and activation of endothelial TLR4 coordinate neutrophil adhesion within liver sinusoids during endotoxemia. Am J Physiol Gastrointest Liver Physiol. 2013; 305(11):G797-806. DOI: 10.1152/ajpgi.00058.2013. View

15.

Zhuo L, Kanamori A, Kannagi R, Itano N, Wu J, Hamaguchi M . SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum. J Biol Chem. 2006; 281(29):20303-14. DOI: 10.1074/jbc.M506703200. View

16.

McDonald B, McAvoy E, Lam F, Gill V, de la Motte C, Savani R . Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids. J Exp Med. 2008; 205(4):915-27. PMC: 2292228. DOI: 10.1084/jem.20071765. View

17.

Xu H, Manivannan A, Liversidge J, Sharp P, Forrester J, Crane I . Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier. J Leukoc Biol. 2002; 72(6):1133-41. View

18.

Johnson J, Hong H, Monfregola J, Catz S . Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation. Infect Immun. 2011; 79(9):3607-18. PMC: 3165471. DOI: 10.1128/IAI.05043-11. View

19.

Zhou B, Weigel J, Fauss L, Weigel P . Identification of the hyaluronan receptor for endocytosis (HARE). J Biol Chem. 2000; 275(48):37733-41. DOI: 10.1074/jbc.M003030200. View

20.

Mohamadzadeh M, DeGrendele H, Arizpe H, Estess P, Siegelman M . Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion. J Clin Invest. 1998; 101(1):97-108. PMC: 508545. DOI: 10.1172/JCI1604. View