Braedon McDonald
Overview
Explore the profile of Braedon McDonald including associated specialties, affiliations and a list of published articles.
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51
Citations
4678
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Recent Articles
1.
Cho N, Strayer K, Dobson B, McDonald B
Gut Microbes
. 2024 May;
16(1):2351478.
PMID: 38780485
For many years, it has been hypothesized that pathological changes to the gut microbiome in critical illness is a driver of infections, organ dysfunction, and other adverse outcomes in the...
2.
Sharma N, Chen A, Heinen L, Liu R, Dwivedi D, Zhou J, et al.
Intensive Care Med Exp
. 2024 Mar;
12(1):28.
PMID: 38457063
Introduction: Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an...
3.
Chiu M, Gershkovich B, Yu I, OBrien E, Deng J, McDonald B
Cell Stress Chaperones
. 2023 Nov;
28(6):877-887.
PMID: 37966617
Acute respiratory distress syndrome (ARDS) is a common cause of hypoxemic respiratory failure in intensive care units that has increased dramatically as a result of the COVID-19 pandemic. In both...
4.
Connor C, Zucoloto A, Munnoch J, Yu I, Corander J, Hoskisson P, et al.
PLoS Biol
. 2023 Oct;
21(10):e3002329.
PMID: 37847672
Extra-intestinal pathogenic Escherichia coli (ExPEC) can cause a variety of infections outside of the intestine and are a major causative agent of urinary tract infections. Treatment of these infections is...
5.
Sharma N, Chwastek D, Dwivedi D, Schlechte J, Yu I, McDonald B, et al.
Intensive Care Med Exp
. 2023 Jul;
11(1):45.
PMID: 37460911
Background: Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis Platform...
6.
Burkhard R, Koegler M, Brown K, Wilson K, Mager L, Zucoloto A, et al.
Front Immunol
. 2023 Jun;
14:1030395.
PMID: 37283756
Healthy host-microbial mutualism with our intestinal microbiota relies to a large degree on compartmentalization and careful regulation of adaptive mucosal and systemic anti-microbial immune responses. However, commensal intestinal bacteria are...
7.
Zucoloto A, Schlechte J, Ignacio A, Thomson C, Pyke S, Yu I, et al.
Cell Rep
. 2023 May;
42(5):112507.
PMID: 37195866
During bloodstream infections, neutrophils home to the liver as part of an intravascular immune response to eradicate blood-borne pathogens, but the mechanisms regulating this crucial response are unknown. Using in ...
8.
Zhang M, Fergusson D, Sharma R, Khoo C, Mendelson A, McDonald B, et al.
Syst Rev
. 2023 Mar;
12(1):50.
PMID: 36945012
Background: The importance of investigating sex- and gender-dependent differences has been recently emphasized by major funding agencies. Notably, the influence of biological sex on clinical outcomes in sepsis is unclear,...
9.
Schlechte J, Zucoloto A, Yu I, Doig C, Dunbar M, McCoy K, et al.
Nat Med
. 2023 Mar;
29(4):1017-1027.
PMID: 36894652
Critically ill patients in intensive care units experience profound alterations of their gut microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections and adverse outcomes through...
10.
Biemond J, McDonald B, Haak B
Curr Opin Crit Care
. 2023 Feb;
29(2):123-129.
PMID: 36762681
Purpose Of Review: This review aims to provide an overview of the current knowledge about microbiota-targeted therapies in sepsis, and calls out - despite recent negative studies - not to...