HBV Infection Among HIV-Infected Cohort and HIV-Negative Hospital Attendees in South Western Nigeria

Overview

Journal Afr J Infect Dis

Date 2015 Feb 28

PMID 25722846

Citations 2

Authors

Moses Olubusuyi Adewumi

Emmanuel Donbraye

Waidi Folorunso Sule

Olaniran Olarinde

Affiliations

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Abstract

Background: Prevalence, association and probable mode of acquisition of HBV and HIV dual infections have not been fully explored. Thus, HBV intervention plan and services are sometimes exclusively targeted towards HIV-infected population. We investigated HBV infection among HIV-infected cohort in comparison with HIV-negative hospital attendees to ascertain dual infectivity pattern; thereby encouraging appropriate allotment of intervention services.

Materials And Methods: A total of 349 (M=141; F=208; Mean=33.98 years; Range= 0.33-80 years) plasma specimens from two virus diagnostic laboratories in south-western Nigeria were analysed. These include 182 HIV-positive and 167 HIV-negative specimens from ART and GDV laboratories respectively. The specimens were initially screened for detectable HIV antigen/antibody, and subsequently HBsAg by ELISA technique.

Results: Overall, HBsAg was detected in 20.92% (95% CI: 16.65-25.19%) of the patients. Also, 24.82% (95% CI: 17.69-31.95%) and 18.27% (95% CI: 13.02-23.52%) HBsAg positivity was recorded for males and females respectively. CHI square analysis showed no association (P=0.14) between gender and prevalence of HBsAg. Similarly, comparison of prevalence of HBsAg by age groups shows no significant difference (P=0.24). Overall, no significant difference (P=0.59) was observed in the prevalence of HBsAg among the HIV-infected cohort and HIV-negative hospital attendees.

Conclusions: Results of the study confirm endemicity and comparable rates of HBV infection independent of HIV-status.

Citing Articles

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Platt L, French C, McGowan C, Sabin K, Gower E, Trickey A J Viral Hepat. 2019; 27(3):294-315.

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References

Rouet F, Chaix M, Inwoley A, Msellati P, Viho I, Combe P . HBV and HCV prevalence and viraemia in HIV-positive and HIV-negative pregnant women in Abidjan, Côte d'Ivoire: the ANRS 1236 study. J Med Virol. 2004; 74(1):34-40. DOI: 10.1002/jmv.20143. View

Ruiz-Moreno M, Otero M, Millan A, Castillo I, Cabrerizo M, Jimenez F . Clinical and histological outcome after hepatitis B e antigen to antibody seroconversion in children with chronic hepatitis B. Hepatology. 1999; 29(2):572-5. DOI: 10.1002/hep.510290230. View

Oshitani H, Kasolo F, Mpabalwani M, Mizuta K, Luo N, Suzuki H . Prevalence of hepatitis B antigens in human immunodeficiency virus type 1 seropositive and seronegative pregnant women in Zambia. Trans R Soc Trop Med Hyg. 1996; 90(3):235-6. DOI: 10.1016/s0035-9203(96)90227-8. View

Mast E, Margolis H, Fiore A, Brink E, Goldstein S, Wang S . A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents. MMWR Recomm Rep. 2005; 54(RR-16):1-31. View

Saha K, Firdaus R, Santra P, Pal J, Roy A, Bhattacharya M . Recent pattern of Co-infection amongst HIV seropositive individuals in tertiary care hospital, Kolkata. Virol J. 2011; 8:116. PMC: 3066117. DOI: 10.1186/1743-422X-8-116. View

. Improved methods and assumptions for estimation of the HIV/AIDS epidemic and its impact: Recommendations of the UNAIDS Reference Group on Estimates, Modelling and Projections. AIDS. 2002; 16(9):W1-14. DOI: 10.1097/00002030-200206140-00024. View

Wiersma S, McMahon B, Pawlotsky J, Thio C, Thursz M, Lim S . Treatment of chronic hepatitis B virus infection in resource-constrained settings: expert panel consensus. Liver Int. 2011; 31(6):755-61. DOI: 10.1111/j.1478-3231.2010.02373.x. View

Shimelis T, Torben W, Medhin G, Tebeje M, Andualm A, Demessie F . Hepatitis B virus infection among people attending the voluntary counselling and testing centre and anti-retroviral therapy clinic of St Paul's General Specialised Hospital, Addis Ababa, Ethiopia. Sex Transm Infect. 2007; 84(1):37-41. DOI: 10.1136/sti.2007.027326. View

Simpore J, Savadogo A, Ilboudo D, Nadambega M, Esposito M, Yara J . Toxoplasma gondii, HCV, and HBV seroprevalence and co-infection among HIV-positive and -negative pregnant women in Burkina Faso. J Med Virol. 2006; 78(6):730-3. DOI: 10.1002/jmv.20615. View

10.

Ejele O, Nwauche C, Erhabor O . The prevalence of hepatitis B surface antigenaemia in HIV positive patients in the Niger Delta Nigeria. Niger J Med. 2004; 13(2):175-9. View

11.

Kiire C . The epidemiology and control of hepatitis B in sub-Saharan Africa. Prog Med Virol. 1993; 40:141-56. View

12.

Iwalokun B, Hodonu S, Olaleye B, Olabisi O . Seroprevalence and biochemical features of hepatitis B surface antigenemia in patients with HIV-1 infection in Lagos, Nigeria. Afr J Med Med Sci. 2007; 35(3):337-43. View

13.

Dusheiko G, Brink B, Conradie J, Marimuthu T, SHER R . Regional prevalence of hepatitis B, delta, and human immunodeficiency virus infection in southern Africa: a large population survey. Am J Epidemiol. 1989; 129(1):138-45. DOI: 10.1093/oxfordjournals.aje.a115102. View

14.

Alter M . Epidemiology of viral hepatitis and HIV co-infection. J Hepatol. 2005; 44(1 Suppl):S6-9. DOI: 10.1016/j.jhep.2005.11.004. View

15.

Bortolotti F, Guido M, Bartolacci S, Cadrobbi P, Crivellaro C, Noventa F . Chronic hepatitis B in children after e antigen seroclearance: final report of a 29-year longitudinal study. Hepatology. 2006; 43(3):556-62. DOI: 10.1002/hep.21077. View

16.

McMahon B, Alward W, Hall D, Heyward W, Bender T, Francis D . Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state. J Infect Dis. 1985; 151(4):599-603. DOI: 10.1093/infdis/151.4.599. View

17.

McQuillan G, Coleman P, Moyer L, Lambert S, Margolis H . Prevalence of hepatitis B virus infection in the United States: the National Health and Nutrition Examination Surveys, 1976 through 1994. Am J Public Health. 1999; 89(1):14-8. PMC: 1508496. DOI: 10.2105/ajph.89.1.14. View

18.

Mahoney F . Update on diagnosis, management, and prevention of hepatitis B virus infection. Clin Microbiol Rev. 1999; 12(2):351-66. PMC: 88921. DOI: 10.1128/CMR.12.2.351. View

19.

Stroffolini T, Mele A, Tosti M, Gallo G, Balocchini E, Ragni P . The impact of the hepatitis B mass immunisation campaign on the incidence and risk factors of acute hepatitis B in Italy. J Hepatol. 2000; 33(6):980-5. DOI: 10.1016/s0168-8278(00)80132-4. View

20.

Fakunle Y, Abdurrahman M, Whittle H . Hepatitis-B virus infection in children and adults in Northern Nigeria: a preliminary survey. Trans R Soc Trop Med Hyg. 1981; 75(5):626-9. DOI: 10.1016/0035-9203(81)90133-4. View