Neutrophils and Inflammatory Metabolism in Antimicrobial Functions of the Mucosa

Overview

Journal J Leukoc Biol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2015 Feb 26

PMID 25714801

Citations 14

Authors

Eric L Campbell

Sean P Colgan

Affiliations

Soon will be listed here.

Abstract

In this mini-review, we will discuss recent findings that implicate neutrophil infiltration and function in establishing a metabolic environment to facilitate efficient pathogen clearance. For decades, neutrophils have been regarded as short lived, nonspecific granulocytes, equipped with toxic antimicrobial factors and a respiratory burst generating ROS. Recent findings demonstrate the importance of HIF signaling in leukocytes and surrounding tissues during inflammation. Here, we will review the potential mechanisms and outcomes of HIF stabilization within the intestinal mucosa.

Citing Articles

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Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19.

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Bidirectional Crosstalk Between Hypoxia Inducible Factors and Glucocorticoid Signalling in Health and Disease.

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Restoring glucose uptake rescues neutrophil dysfunction and protects against systemic fungal infection in mouse models of kidney disease.

Jawale C, Ramani K, Li D, Coleman B, Oberoi R, Kupul S Sci Transl Med. 2020; 12(548).

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Selective pressures during chronic infection drive microbial competition and cooperation.

Baishya J, Wakeman C NPJ Biofilms Microbiomes. 2019; 5(1):16.

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