The Role of Pattern Recognition Receptors in the Innate Recognition of Candida Albicans

Overview

Journal Virulence

Specialty Microbiology

Date 2015 Feb 26

PMID 25714264

Citations 23

Authors

Nan-Xin Zheng

Yan Wang

Dan-Dan Hu

Lan Yan

Yuan-Ying Jiang

Affiliations

Soon will be listed here.

Abstract

Candida albicans is both a commensal microorganism in healthy individuals and a major fungal pathogen causing high mortality in immunocompromised patients. Yeast-hypha morphological transition is a well known virulence trait of C. albicans. Host innate immunity to C. albicans critically requires pattern recognition receptors (PRRs). In this review, we summarize the PRRs involved in the recognition of C. albicans in epithelial cells, endothelial cells, and phagocytic cells separately. We figure out the differential recognition of yeasts and hyphae, the findings on PRR-deficient mice, and the discoveries on human PRR-related single nucleotide polymorphisms (SNPs).

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