Local Drug and Gene Delivery Through Microbubbles and Ultrasound

Overview

Journal Neth Heart J

Specialty Cardiology & Vascular Diseases

Date 2015 Feb 20

PMID 25696370

Citations 5

Authors

L J M Juffermans

P A Dijkmans

R J P Musters

A van Wamel

A Bouakaz

F J Ten Cate

L Deelman

C A Visser

N de Jong

O Kamp

Affiliations

Soon will be listed here.

Abstract

Although gene therapy has great potential as a treatment for diseases, clinical trials are slowed down by the development of a safe and efficient gene delivery system. In this review, we will give an overview of the viral and nonviral vehicles used for drug and gene delivery, and the different nonviral delivery techniques, thereby focusing on delivery through ultrasound contrast agents. The development of ultrasound contrast agents containing encapsulated microbubbles has increased the possibilities not only for diagnostic imaging, but for therapy as well. Microbubbles have been shown to be able to carry drugs and genes, and destruction of the bubbles by ultrasound will result in local release of their contents. Furthermore, ligands can be attached so that they can be targeted to a specific target tissue. The recent advances of microbubbles as vehicles for delivery of drugs and genes will be highlighted.

Citing Articles

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Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery.

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Oxygen supersaturated fluid using fine micro/nanobubbles.

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New chitosan nanobubbles for ultrasound-mediated gene delivery: preparation and in vitro characterization.

Cavalli R, Bisazza A, Trotta M, Argenziano M, Civra A, Donalisio M Int J Nanomedicine. 2012; 7:3309-18.

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Blood oxygenation using microbubble suspensions.

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