Cervical Mass As the Presenting Manifestation of Hepatocellular Carcinoma

Overview

Journal Hippokratia

Specialty General Medicine

Date 2015 Feb 20

PMID 25694768

Citations 2

Authors

Ng Vallianou

P Gounari

A Skourtis

C Vourlakou

Affiliations

Soon will be listed here.

Abstract

Background: Hepatocellular carcinoma is one of the most common cancers in the world due to its association with chronic hepatitis infections. Amongst the most usual metastasis of hepatocellular carcinoma are the lymph nodes, the lungs and the bones. Soft tissue metastases are extremely rare.

Case Presentation: Herein, we report the case of a 73-years-old male patient who presented with cervical and upper extremities muscle pain along with paresthesias and a palpable mass on the cervical region.

Conclusion: This unusual clinical manifestation along with the above-described rare presentations of hepatocellular carcinoma must be taken into account, especially among patients with chronic hepatitis infections. Hippokratia 2014; 18 (3): 285-287.

Citing Articles

Hepatocellular carcinoma presenting as spinal cord compression in Native Americans with controlled hepatitis C: two case reports.

Liaukovich M, Wu S, Yoon S, Schaffer J, Wang J J Med Case Rep. 2018; 12(1):282.

PMID: 30268151 PMC: 6164177. DOI: 10.1186/s13256-018-1807-8.

Cervical Spinal Cord Compression: A Rare Presentation of Hepatocellular Carcinoma.

Ayyadurai P, Badipatla K, Chime C, Arjun S, Reddy P, Niazi M Case Reports Hepatol. 2017; 2017:8567695.

PMID: 28299213 PMC: 5337315. DOI: 10.1155/2017/8567695.

References

EDMONDSON H, STEINER P . Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954; 7(3):462-503. DOI: 10.1002/1097-0142(195405)7:3<462::aid-cncr2820070308>3.0.co;2-e. View

Si M, Amersi F, Golish S, Ortiz J, Zaky J, Finklestein D . Prevalence of metastases in hepatocellular carcinoma: risk factors and impact on survival. Am Surg. 2003; 69(10):879-85. View

UyBarreta V, Mikesh C, Simmons B, Beech D . Atypical presentation of hepatocellular carcinoma. South Med J. 2000; 93(5):516-9. View

Kim S, Chun M, Wang H, Cho S, Oh Y, Kang S . Bone metastasis from primary hepatocellular carcinoma: characteristics of soft tissue formation. Cancer Res Treat. 2009; 39(3):104-8. PMC: 2739323. DOI: 10.4143/crt.2007.39.3.104. View

Luo C, Jiang Y, Liu Y . [Preliminary study on skeletal muscle derived tumor suppressor]. Zhonghua Zhong Liu Za Zhi. 2002; 23(1):17-20. View

Koike Y, Hatori M, Kokubun S . Skeletal muscle metastasis secondary to cancer--a report of seven cases. Ups J Med Sci. 2005; 110(1):75-83. DOI: 10.3109/2000-1967-183. View

Attili V, Govind Babu K, Lokanatha D, Bapsy P, Ramachandra C, Rajshekar H . Bone metastasis in hepatocellular carcinoma: need for reappraisal of treatment. J Cancer Res Ther. 2008; 4(2):93-4. DOI: 10.4103/0973-1482.42257. View

Chandra Doval D, Bhatia K, Vaid A, Pavithran K, Sharma J, Hazarika D . Spinal cord compression secondary to bone metastases from hepatocellular carcinoma. World J Gastroenterol. 2006; 12(32):5247-52. PMC: 4088031. DOI: 10.3748/wjg.v12.i32.5247. View

Tamaki K, Shimizu I, Urata M, Kohno N, Fukuno H, Ito S . A patient with spinal metastasis from hepatocellular carcinoma discovered from neurological findings. World J Gastroenterol. 2007; 13(19):2758-60. PMC: 4147130. DOI: 10.3748/wjg.v13.i19.2758. View

10.

Katyal S, Oliver 3rd J, Peterson M, Ferris J, Carr B, BARON R . Extrahepatic metastases of hepatocellular carcinoma. Radiology. 2000; 216(3):698-703. DOI: 10.1148/radiology.216.3.r00se24698. View

11.

Michalaki V, Zygogianni A, Kouloulias V, Balafouta M, Vlachodimitropoulos D, Gennatas C . Muscle metastasis from hepatocellular carcinoma. J Cancer Res Ther. 2011; 7(1):81-3. DOI: 10.4103/0973-1482.80467. View

12.

Natsuizaka M, Omura T, Akaike T, Kuwata Y, Yamazaki K, Sato T . Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol. 2005; 20(11):1781-7. DOI: 10.1111/j.1440-1746.2005.03919.x. View

13.

Terada T, Maruo H . Unusual extrahepatic metastatic sites from hepatocellular carcinoma. Int J Clin Exp Pathol. 2013; 6(5):816-20. PMC: 3638091. View

14.

Braune C, Widjaja A, Bartels M, Bleck J, Flemming P, Manns M . Surgical removal of a distinct subcutaneous metastasis of multilocular hepatocellular carcinoma 2 months after initial percutaneous ethanol injection therapy. Z Gastroenterol. 2001; 39(9):789-92. DOI: 10.1055/s-2001-17188. View

15.

Hedri H, Mhibik S, Abderrahim E, Goucha R, Ben Taarit C, Kheder A . [Sternal metastasis revealing hepatocarcinoma]. Rev Med Interne. 2004; 25(3):238-41. DOI: 10.1016/j.revmed.2003.12.005. View

16.

Jo S, Shim H . A patient who has survived for a long period with repeated radiotherapies for multifocal extrahepatic metastases from hepatocellular carcinoma. Radiat Oncol J. 2014; 31(4):267-72. PMC: 3912243. DOI: 10.3857/roj.2013.31.4.267. View