A Statistically Inferred MicroRNA Network Identifies Breast Cancer Target MiR-940 As an Actin Cytoskeleton Regulator

Overview

Journal Sci Rep

Specialty Science

Date 2015 Feb 13

PMID 25673565

Citations 17

Authors

Ricky Bhajun

Laurent Guyon

Amandine Pitaval

Eric Sulpice

Stephanie Combe

Patricia Obeid

Vincent Haguet

Itebeddine Ghorbel

Christian Lajaunie

Xavier Gidrol

Affiliations

Soon will be listed here.

Abstract

MiRNAs are key regulators of gene expression. By binding to many genes, they create a complex network of gene co-regulation. Here, using a network-based approach, we identified miRNA hub groups by their close connections and common targets. In one cluster containing three miRNAs, miR-612, miR-661 and miR-940, the annotated functions of the co-regulated genes suggested a role in small GTPase signalling. Although the three members of this cluster targeted the same subset of predicted genes, we showed that their overexpression impacted cell fates differently. miR-661 demonstrated enhanced phosphorylation of myosin II and an increase in cell invasion, indicating a possible oncogenic miRNA. On the contrary, miR-612 and miR-940 inhibit phosphorylation of myosin II and cell invasion. Finally, expression profiling in human breast tissues showed that miR-940 was consistently downregulated in breast cancer tissues.

Citing Articles

JHDM1D-AS1-driven inhibition of miR-940 releases ARTN expression to induce breast carcinogenesis.

Zuo Y, Ma M, Wen Y, Chang L, Qu C Clin Transl Oncol. 2023; 25(7):2192-2203.

PMID: 36862282 DOI: 10.1007/s12094-023-03102-y.

MicroRNAs Regulating Cytoskeleton Dynamics, Endocytosis, and Cell Motility-A Link Between Neurodegeneration and Cancer?.

Gerasymchuk D, Hubiernatorova A, Domanskyi A Front Neurol. 2020; 11:549006.

PMID: 33240194 PMC: 7680873. DOI: 10.3389/fneur.2020.549006.

The Highlighted Roles of Metabolic and Cellular Response to Stress Pathways Engaged in Circulating hsa-miR-494-3p and hsa-miR-661 in Alzheimer's Disease.

Hojati Z, Omidi F, Dehbashi M, Mohammad Soltani B Iran Biomed J. 2020; 25(1):62-7.

PMID: 33129241 PMC: 7748118. DOI: 10.29252/ibj.25.1.62.

Argonaute4 Modulates Resistance to Infection by Regulating Jasmonic Acid Signaling.

Pradhan M, Pandey P, Baldwin I, Pandey S Plant Physiol. 2020; 184(2):1128-1152.

PMID: 32723807 PMC: 7536687. DOI: 10.1104/pp.20.00171.

miRViz: a novel webserver application to visualize and interpret microRNA datasets.

Giroux P, Bhajun R, Segard S, Picquenot C, Charavay C, Desquilles L Nucleic Acids Res. 2020; 48(W1):W252-W261.

PMID: 32319523 PMC: 7319447. DOI: 10.1093/nar/gkaa259.

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