Association Between Coronary Artery Calcification and Left Ventricular Diastolic Dysfunction in Elderly People

Overview

Journal Heart Vessels

Specialty Cardiology & Vascular Diseases

Date 2015 Feb 13

PMID 25673497

Citations 10

Authors

Kazuhiro Osawa

Toru Miyoshi

Hiroki Oe

Shuhei Sato

Kazufumi Nakamura

Kunihisa Kohno

Hiroshi Morita

Susumu Kanazawa

Hiroshi Ito

Affiliations

Soon will be listed here.

Abstract

Coronary artery calcification (CAC) is associated with the incidence of congestive heart failure. We evaluated the association between CAC and left ventricular diastolic dysfunction (LVDD) in elderly patients without coronary artery disease. Coronary computed tomography was performed in 1,021 consecutive patients >55 years of age who were suspected of having coronary artery disease. A total of 530 patients (age, 70 ± 8 years; 56 % men) with a LV ejection fraction >50 % and without obstructive coronary artery disease and a history of coronary artery disease were included in the analysis. LVDD was defined according to a standard algorithm by echocardiography (septal e' <8, lateral e' <10, and left atrial volume index ≥34 mL/m(2)). A total of 224 of 530 patients had LVDD. CAC scores in patients with LVDD were higher than those in patients without LVDD (p < 0.01). The prevalence of LVDD in patients with CAC scores ≥400 was greater than that in patients with CAC scores of 0-9 (58 vs. 34 %, p < 0.01). After adjustment for confounding factors, the CAC score was associated with LVDD, with an odds ratio of 1.96 (95 % confidence interval: 1.11-3.43, p = 0.02) for a CAC score ≥400 compared with a CAC score of 0-9. A CAC score ≥400 was associated with LVDD in elderly patients without CAD in this population. Further prospective studies are needed to evaluate the clinical relevance of CAC as a risk of heart failure with preserved ejection fraction.

Citing Articles

Are Non-Invasive Modalities for the Assessment of Atherosclerosis Useful for Heart Failure Predictions?.

Osawa K, Miyoshi T Int J Mol Sci. 2023; 24(3).

PMID: 36768247 PMC: 9916375. DOI: 10.3390/ijms24031925.

Association of Left Ventricular Diastolic Dysfunction With Cardiovascular Outcomes in Patients With Pre-dialysis Chronic Kidney Disease: Findings From KNOW-CKD Study.

Suh S, Oh T, Choi H, Kim C, Bae E, Oh K Front Cardiovasc Med. 2022; 9:844312.

PMID: 35402554 PMC: 8990123. DOI: 10.3389/fcvm.2022.844312.

Echocardiographic parameters of left ventricular structure and diastolic function and their relation to coronary artery calcification.

Park S, Kang J, Seok H, Jung J Int J Cardiovasc Imaging. 2021; 37(10):2861-2869.

PMID: 33945053 DOI: 10.1007/s10554-021-02256-6.

Effects of Eicosapentaenoic Acid on Arterial Calcification.

Saito Y, Nakamura K, Ito H Int J Mol Sci. 2020; 21(15).

PMID: 32751754 PMC: 7432365. DOI: 10.3390/ijms21155455.

Association of subclinical atherosclerosis with echocardiographic indices of cardiac remodeling: The Framingham Study.

Castro-Diehl C, Song R, Mitchell G, McManus D, Cheng S, Vasan R PLoS One. 2020; 15(5):e0233321.

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