Multicolored Silver Nanoparticles for Multiplexed Disease Diagnostics: Distinguishing Dengue, Yellow Fever, and Ebola Viruses

Overview

Journal Lab Chip

Publisher Royal Society of Chemistry

Specialties Biotechnology
Chemistry

Date 2015 Feb 13

PMID 25672590

Citations 92

Authors

Chun-Wan Yen

Helena de Puig

Justina O Tam

Jose Gomez-Marquez

Irene Bosch

Kimberly Hamad-Schifferli

Lee Gehrke

Affiliations

Soon will be listed here.

Abstract

Rapid point-of-care (POC) diagnostic devices are needed for field-forward screening of severe acute systemic febrile illnesses. Multiplexed rapid lateral flow diagnostics have the potential to distinguish among multiple pathogens, thereby facilitating diagnosis and improving patient care. Here, we present a platform for multiplexed pathogen detection using multi-colored silver nanoplates. This design requires no external excitation source and permits multiplexed analysis in a single channel, facilitating integration and manufacturing.

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References

Sherry L, Jin R, Mirkin C, Schatz G, Van Duyne R . Localized surface plasmon resonance spectroscopy of single silver triangular nanoprisms. Nano Lett. 2006; 6(9):2060-5. DOI: 10.1021/nl061286u. View

Homan K, Souza M, Truby R, Luke G, Green C, Vreeland E . Silver nanoplate contrast agents for in vivo molecular photoacoustic imaging. ACS Nano. 2011; 6(1):641-50. PMC: 3747830. DOI: 10.1021/nn204100n. View

Geissler D, Charbonniere L, Ziessel R, Butlin N, Lohmannsroben H, Hildebrandt N . Quantum dot biosensors for ultrasensitive multiplexed diagnostics. Angew Chem Int Ed Engl. 2010; 49(8):1396-401. DOI: 10.1002/anie.200906399. View

Hauck T, Giri S, Gao Y, Chan W . Nanotechnology diagnostics for infectious diseases prevalent in developing countries. Adv Drug Deliv Rev. 2009; 62(4-5):438-48. DOI: 10.1016/j.addr.2009.11.015. View

Li Z, Wang Y, Wang J, Tang Z, Pounds J, Lin Y . Rapid and sensitive detection of protein biomarker using a portable fluorescence biosensor based on quantum dots and a lateral flow test strip. Anal Chem. 2010; 82(16):7008-14. DOI: 10.1021/ac101405a. View

Li C, Vandenberg K, Prabhulkar S, Zhu X, Schneper L, Methee K . Paper based point-of-care testing disc for multiplex whole cell bacteria analysis. Biosens Bioelectron. 2011; 26(11):4342-8. DOI: 10.1016/j.bios.2011.04.035. View

Vashist S, Mudanyali O, Schneider E, Zengerle R, Ozcan A . Cellphone-based devices for bioanalytical sciences. Anal Bioanal Chem. 2013; 406(14):3263-77. PMC: 4024356. DOI: 10.1007/s00216-013-7473-1. View

Shen L, Hagen J, Papautsky I . Point-of-care colorimetric detection with a smartphone. Lab Chip. 2012; 12(21):4240-3. DOI: 10.1039/c2lc40741h. View

Parolo C, Merkoci A . Paper-based nanobiosensors for diagnostics. Chem Soc Rev. 2012; 42(2):450-7. DOI: 10.1039/c2cs35255a. View

10.

Wang H, Tsai C, Chen K, Tang C, Leou J, Li P . Cellulose-based diagnostic devices for diagnosing serotype-2 dengue fever in human serum. Adv Healthc Mater. 2013; 3(2):187-96. DOI: 10.1002/adhm.201300150. View

11.

Cordray M, Amdahl M, Richards-Kortum R . Gold nanoparticle aggregation for quantification of oligonucleotides: optimization and increased dynamic range. Anal Biochem. 2012; 431(2):99-105. PMC: 3496753. DOI: 10.1016/j.ab.2012.09.013. View

12.

Nash M, Waitumbi J, Hoffman A, Yager P, Stayton P . Multiplexed enrichment and detection of malarial biomarkers using a stimuli-responsive iron oxide and gold nanoparticle reagent system. ACS Nano. 2012; 6(8):6776-85. PMC: 4085275. DOI: 10.1021/nn3015008. View

13.

Chung K, Nybakken G, Thompson B, Engle M, Marri A, Fremont D . Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms. J Virol. 2006; 80(3):1340-51. PMC: 1346945. DOI: 10.1128/JVI.80.3.1340-1351.2006. View

14.

Yetisen A, Akram M, Lowe C . Paper-based microfluidic point-of-care diagnostic devices. Lab Chip. 2013; 13(12):2210-51. DOI: 10.1039/c3lc50169h. View

15.

Fenton E, Mascarenas M, Lopez G, Sibbett S . Multiplex lateral-flow test strips fabricated by two-dimensional shaping. ACS Appl Mater Interfaces. 2010; 1(1):124-9. DOI: 10.1021/am800043z. View

16.

Alcon S, Talarmin A, Debruyne M, Falconar A, Deubel V, Flamand M . Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections. J Clin Microbiol. 2002; 40(2):376-81. PMC: 153354. DOI: 10.1128/JCM.40.02.376-381.2002. View

17.

Young P, Hilditch P, Bletchly C, HALLORAN W . An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients. J Clin Microbiol. 2000; 38(3):1053-7. PMC: 86336. DOI: 10.1128/JCM.38.3.1053-1057.2000. View

18.

Mahmoud M, ONeil D, El-Sayed M . Shape- and symmetry-dependent mechanical properties of metallic gold and silver on the nanoscale. Nano Lett. 2013; 14(2):743-8. DOI: 10.1021/nl4040362. View

19.

Huang X, Jain P, El-Sayed I, El-Sayed M . Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine (Lond). 2007; 2(5):681-93. DOI: 10.2217/17435889.2.5.681. View

20.

Zheng G, Patolsky F, Cui Y, Wang W, Lieber C . Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nat Biotechnol. 2005; 23(10):1294-301. DOI: 10.1038/nbt1138. View