Age-associated Pro-inflammatory Remodeling and Functional Phenotype in the Heart and Large Arteries

Overview

Journal J Mol Cell Cardiol

Specialty Cardiology & Vascular Diseases

Date 2015 Feb 11

PMID 25665458

Citations 41

Authors

Mingyi Wang

Ajay M Shah

Affiliations

Soon will be listed here.

Abstract

The aging population is increasing dramatically. Aging-associated stress simultaneously drives proinflammatory remodeling, involving angiotensin II and other factors, in both the heart and large arteries. The structural remodeling and functional changes that occur with aging include cardiac and vascular wall stiffening, systolic hypertension and suboptimal ventricular-arterial coupling, features that are often clinically silent and thus termed a silent syndrome. These age-related effects are the result of responses initiated by cardiovascular proinflammatory cells. Local proinflammatory signals are coupled between the heart and arteries due to common mechanical and humoral messengers within a closed circulating system. Thus, targeting proinflammatory signaling molecules would be a promising approach to improve age-associated suboptimal ventricular-arterial coupling, a major predisposing factor for the pathogenesis of clinical cardiovascular events such as heart failure.

Citing Articles

Bioinformatics approach reveals the critical role of inflammation-related genes in age-related hearing loss.

Gu X, Chen C, Chen Y, Zeng C, Lin Y, Guo R Sci Rep. 2025; 15(1):2687.

PMID: 39837906 PMC: 11751394. DOI: 10.1038/s41598-024-83428-x.

Cardiac tissue-resident vesicles differentially modulate anti-fibrotic phenotype by age and sex through synergistic miRNA effects.

Ronan G, Bahcecioglu G, Yang J, Zorlutuna P Biomaterials. 2024; 311:122671.

PMID: 38941684 PMC: 11344275. DOI: 10.1016/j.biomaterials.2024.122671.

The role of cardiac resident macrophage in cardiac aging.

Li J, Xin Y, Wang Z, Li J, Li W, Li H Aging Cell. 2023; 22(12):e14008.

PMID: 37817547 PMC: 10726886. DOI: 10.1111/acel.14008.

The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review.

Xu J, Yu L, Liu F, Wan L, Deng Z Front Immunol. 2023; 14:1222129.

PMID: 37475866 PMC: 10355373. DOI: 10.3389/fimmu.2023.1222129.

Polarizing Macrophage Functional Phenotype to Foster Cardiac Regeneration.

Molinaro C, Scalise M, Leo I, Salerno L, Sabatino J, Salerno N Int J Mol Sci. 2023; 24(13).

PMID: 37445929 PMC: 10341872. DOI: 10.3390/ijms241310747.

References

Roos C, Hagler M, Zhang B, Oehler E, Arghami A, Miller J . Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice. Am J Physiol Heart Circ Physiol. 2013; 305(10):H1428-39. PMC: 3840262. DOI: 10.1152/ajpheart.00735.2012. View

Wang M, Monticone R, Lakatta E . Arterial aging: a journey into subclinical arterial disease. Curr Opin Nephrol Hypertens. 2009; 19(2):201-7. PMC: 2943205. DOI: 10.1097/MNH.0b013e3283361c0b. View

Chen X, Li Z, Feng Z, Wang J, Ouyang C, Liu W . Integrin-linked kinase induces both senescence-associated alterations and extracellular fibronectin assembly in aging cardiac fibroblasts. J Gerontol A Biol Sci Med Sci. 2007; 61(12):1232-45. DOI: 10.1093/gerona/61.12.1232. View

Satoh T, Sasatomi E, Yamasaki F, Ishida H, Wu L, Tokunaga O . Multinucleated variant endothelial cells (MVECs) of human aorta: expression of tumor suppressor gene p53 and relationship to atherosclerosis and aging. Endothelium. 1999; 6(2):123-32. DOI: 10.3109/10623329809072199. View

Qiu H, Zhu Y, Sun Z, Trzeciakowski J, Gansner M, Depre C . Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging. Circ Res. 2010; 107(5):615-9. PMC: 2936100. DOI: 10.1161/CIRCRESAHA.110.221846. View

Ferrini M, Davila H, Valente E, Gonzalez-Cadavid N, Rajfer J . Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media. Cardiovasc Res. 2004; 61(4):796-805. DOI: 10.1016/j.cardiores.2003.12.006. View

Wang M, Zhang J, Walker S, Dworakowski R, Lakatta E, Shah A . Involvement of NADPH oxidase in age-associated cardiac remodeling. J Mol Cell Cardiol. 2010; 48(4):765-72. PMC: 2877878. DOI: 10.1016/j.yjmcc.2010.01.006. View

Wang M, Wang H, Lakatta E . Milk fat globule epidermal growth factor VIII signaling in arterial wall remodeling. Curr Vasc Pharmacol. 2012; 11(5):768-76. PMC: 3398225. DOI: 10.2174/1570161111311050014. View

Loffredo F, Steinhauser M, Jay S, Gannon J, Pancoast J, Yalamanchi P . Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013; 153(4):828-39. PMC: 3677132. DOI: 10.1016/j.cell.2013.04.015. View

10.

Baur J . Resveratrol, sirtuins, and the promise of a DR mimetic. Mech Ageing Dev. 2010; 131(4):261-9. PMC: 2862768. DOI: 10.1016/j.mad.2010.02.007. View

11.

Tang Y, Xu J, Qu W, Peng X, Xin P, Yang X . Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms. J Nutr Biochem. 2012; 23(11):1410-6. DOI: 10.1016/j.jnutbio.2011.08.008. View

12.

Li Z, Froehlich J, Galis Z, Lakatta E . Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats. Hypertension. 1999; 33(1):116-23. DOI: 10.1161/01.hyp.33.1.116. View

13.

Novella S, Dantas A, Segarra G, Vidal-Gomez X, Mompeon A, Garabito M . Aging-related endothelial dysfunction in the aorta from female senescence-accelerated mice is associated with decreased nitric oxide synthase expression. Exp Gerontol. 2013; 48(11):1329-37. DOI: 10.1016/j.exger.2013.08.003. View

14.

Wang M, Zhang J, Spinetti G, Jiang L, Monticone R, Zhao D . Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats. Am J Pathol. 2005; 167(5):1429-42. PMC: 1603787. DOI: 10.1016/S0002-9440(10)61229-1. View

15.

Merkin S, Karlamangla A, Diez Roux A, Shrager S, Seeman T . Life course socioeconomic status and longitudinal accumulation of allostatic load in adulthood: multi-ethnic study of atherosclerosis. Am J Public Health. 2014; 104(4):e48-55. PMC: 4025706. DOI: 10.2105/AJPH.2013.301841. View

16.

Maegdefessel L, Azuma J, Toh R, Deng A, Merk D, Raiesdana A . MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med. 2012; 4(122):122ra22. PMC: 5753594. DOI: 10.1126/scitranslmed.3003441. View

17.

Ma Y, Chiao Y, Zhang J, Manicone A, Jin Y, Lindsey M . Matrix metalloproteinase-28 deletion amplifies inflammatory and extracellular matrix responses to cardiac aging. Microsc Microanal. 2011; 18(1):81-90. PMC: 3972008. DOI: 10.1017/S1431927611012220. View

18.

Zouein F, de Castro Bras L, da Costa D, Lindsey M, Kurdi M, Booz G . Heart failure with preserved ejection fraction: emerging drug strategies. J Cardiovasc Pharmacol. 2013; 62(1):13-21. PMC: 3724214. DOI: 10.1097/FJC.0b013e31829a4e61. View

19.

Kliche K, Jeggle P, Pavenstadt H, Oberleithner H . Role of cellular mechanics in the function and life span of vascular endothelium. Pflugers Arch. 2011; 462(2):209-17. DOI: 10.1007/s00424-011-0929-2. View

20.

Ishida W, Mori Y, Lakos G, Sun L, Shan F, Bowes S . Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo. J Invest Dermatol. 2006; 126(8):1733-44. DOI: 10.1038/sj.jid.5700303. View