Involvement of Long Non-coding RNA in Colorectal Cancer: From Benchtop to Bedside (Review)

Overview

Journal Oncol Lett

Specialty Oncology

Date 2015 Feb 10

PMID 25663854

Citations 26

Authors

Le-Chi Ye

De-Xiang Zhu

Jun-Jun Qiu

Jianmin Xu

Ye Wei

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) is one of the greatest threats to public health. Recent advances in whole-genome transcriptome analyses have enabled the identification of numerous members of a novel class of non-coding (nc)RNA, long ncRNA (lncRNA), which is broadly defined as RNA molecules that are >200 nt in length and lacking an open reading frame. In the present review, all lncRNAs associated with CRC are briefly summarized, with a particular focus on their potential roles as clinical biomarkers. CRC-associated lncRNAs involved in the underlying mechanisms of CRC progression are also initially included. This should benefit the development of novel markers and effective therapeutic targets for patients with CRC.

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