Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer

Overview

Journal Clin Colorectal Cancer

Publisher Elsevier

Specialties Gastroenterology
Oncology

Date 2015 Feb 7

PMID 25657049

Citations 23

Authors

Maiken Lise Marcker Espersen

Jesper Olsen

Dorte Linnemann

Estrid Hogdall

Jesper T Troelsen

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) still has one of the highest incidence and mortality rate among cancers. Therefore, improved differential diagnostics and personalized treatment are still needed. Several intestinal stem cell markers have been found to be associated with CRC and might have a prognostic and predictive significance in CRC patients. This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell-specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC. The exact roles of the intestinal stem cell markers in CRC development and progression remain unclear; however, high expression of these stem cell markers have a potential prognostic significance and might be implicated in chemotherapy resistance.

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