Molecular Regulation After Mucosal Injury and Regeneration in Ulcerative Colitis

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2022 Oct 31

PMID 36310594

Authors

Lie Zheng

Sheng-Lei Duan

Xin-Li Wen

Yan-Cheng Dai

Affiliations

Soon will be listed here.

Abstract

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with a complex etiology. Intestinal mucosal injury is an important pathological change in individuals with UC. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5+) intestinal stem cells (ISCs) exhibit self-renewal and high differentiation potential and play important roles in the repair of intestinal mucosal injury. Moreover, LGR5+ ISCs are intricately regulated by both the Wnt/β-catenin and Notch signaling pathways, which jointly maintain the function of LGR5+ ISCs. Combination therapy targeting multiple signaling pathways and transplantation of LGR5+ ISCs may lead to the development of new clinical therapies for UC.

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