Porphyromonas Gingivalis Virulence Factors Involved in Subversion of Leukocytes and Microbial Dysbiosis

Overview

Journal Virulence

Specialty Microbiology

Date 2015 Feb 6

PMID 25654623

Citations 70

Authors

Camille Zenobia

George Hajishengallis

Affiliations

Soon will be listed here.

Abstract

The oral bacterium Porphyromonas gingivalis has special nutrient requirements due to its asaccharolytic nature subsisting on small peptides cleaved from host proteins. Using proteases and other virulence factors, P. gingivalis thrives as a component of a polymicrobial community in nutritionally favorable inflammatory environments. In this regard, P. gingivalis has a number of strategies that subvert the host immune response in ways that promote its colonization and facilitate the outgrowth of the surrounding microbial community. The focus of this review is to discuss at the molecular level how P. gingivalis subverts leukocytes to create a favorable environment for a select community of bacteria that, in turn, adversely affects the periodontal tissues.

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