Isolated Vitamin D Deficiency is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity

Overview

Journal ScientificWorldJournal

Publisher Wiley

Specialty Biology

Date 2015 Feb 6

PMID 25654127

Citations 12

Authors

Muyesser Sayki Arslan

Oya Topaloglu

Bekir Ucan

Melia Karakose

Basak Karbek

Esra Tutal

Mustafa Caliskan

Zeynep Ginis

Erman Cakal

Mustafa Sahin

Mustafa Ozbek

Tuncay Delibasi

Affiliations

Soon will be listed here.

Abstract

Aim: This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level.

Materials And Methods: The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated.

Results: Anti-TPO positivity was significantly more common in those with severe and moderate vitamin D deficiency, as compared to those with a normal 25(OH)D level. Furthermore, TSH levels were significantly lower in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level. Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant.

Conclusions: The prevalence of thyroid autoantibody positivity was higher in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. Additional large-scale studies must be conducted to determine if vitamin D deficiency plays a causal role in the pathogenesis of Hashimoto's thyroiditis and NTIS.

Citing Articles

Impact of Vitamin D on Immunopathology of Hashimoto's Thyroiditis: From Theory to Practice.

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The Role of Vitamin D in Autoimmune Thyroid Diseases: A Narrative Review.

Czarnywojtek A, Florek E, Pietronczyk K, Sawicka-Gutaj N, Ruchala M, Ronen O J Clin Med. 2023; 12(4).

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Vitamin D and the Thyroid: A Critical Review of the Current Evidence.

Babic Leko M, Juresko I, Rozic I, Pleic N, Gunjaca I, Zemunik T Int J Mol Sci. 2023; 24(4).

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The correlation between vitamin D and levels of IFN-γ, NF-κB, thyroid antibodies in down syndrome: study in Indonesian children.

Hisbiyah Y, Endaryanto A, Setyoboedi B, Rochmah N, Faizi M Acta Biomed. 2022; 93(6):e2022342.

PMID: 36533745 PMC: 9828918. DOI: 10.23750/abm.v93i6.13722.

Hashimoto's thyroiditis and coexisting disorders in correlation with HLA status-an overview.

Mikosch P, Aistleitner A, Oehrlein M, Trifina-Mikosch E Wien Med Wochenschr. 2021; 173(1-2):41-53.

PMID: 34524590 PMC: 9877058. DOI: 10.1007/s10354-021-00879-x.

References

Veldman C, Cantorna M, DeLuca H . Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys. 2000; 374(2):334-8. DOI: 10.1006/abbi.1999.1605. View

DeLuca H, Cantorna M . Vitamin D: its role and uses in immunology. FASEB J. 2001; 15(14):2579-85. DOI: 10.1096/fj.01-0433rev. View

Feng M, Li H, Chen S, Li W, Zhang F . Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Endocrine. 2012; 43(2):318-26. DOI: 10.1007/s12020-012-9812-y. View

Peeters R, Wouters P, Kaptein E, van Toor H, Visser T, Van den Berghe G . Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients. J Clin Endocrinol Metab. 2003; 88(7):3202-11. DOI: 10.1210/jc.2002-022013. View

van der Poll T, Romijn J, Wiersinga W, Sauerwein H . Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man. J Clin Endocrinol Metab. 1990; 71(6):1567-72. DOI: 10.1210/jcem-71-6-1567. View

Kankova M, Luini W, Pedrazzoni M, Riganti F, Sironi M, Bottazzi B . Impairment of cytokine production in mice fed a vitamin D3-deficient diet. Immunology. 1991; 73(4):466-71. PMC: 1384578. View

Cantorna M, Zhu Y, Froicu M, Wittke A . Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr. 2004; 80(6 Suppl):1717S-20S. DOI: 10.1093/ajcn/80.6.1717S. View

Gouveia C, Christoffolete M, Zaitune C, Dora J, Harney J, Maia A . Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology. 2004; 146(1):195-200. DOI: 10.1210/en.2004-1043. View

Maia A, Kim B, Huang S, Harney J, Larsen P . Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest. 2005; 115(9):2524-33. PMC: 1190373. DOI: 10.1172/JCI25083. View

10.

Lin W, Wan L, Tsai C, Chen R, Lee C, Tsai F . Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto's thyroiditis in Chinese patients in Taiwan. J Clin Lab Anal. 2006; 20(3):109-12. PMC: 6807492. DOI: 10.1002/jcla.20110. View

11.

Li H, Verginis P, Carayanniotis G . Maturation of dendritic cells by necrotic thyrocytes facilitates induction of experimental autoimmune thyroiditis. Clin Exp Immunol. 2006; 144(3):467-74. PMC: 1941967. DOI: 10.1111/j.1365-2249.2006.03080.x. View

12.

Plikat K, Langgartner J, Buettner R, Bollheimer L, Woenckhaus U, Scholmerich J . Frequency and outcome of patients with nonthyroidal illness syndrome in a medical intensive care unit. Metabolism. 2007; 56(2):239-44. DOI: 10.1016/j.metabol.2006.09.020. View

13.

Stefanic M, Papic S, Suver M, Glavas-Obrovac L, Karner I . Association of vitamin D receptor gene 3'-variants with Hashimoto's thyroiditis in the Croatian population. Int J Immunogenet. 2008; 35(2):125-31. DOI: 10.1111/j.1744-313X.2008.00748.x. View

14.

Melamed M, Michos E, Post W, Astor B . 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008; 168(15):1629-37. PMC: 2677029. DOI: 10.1001/archinte.168.15.1629. View

15.

Kuo Y, Kuo C, Lam K, Chu Y, Wang W, Huang C . Effects of vitamin D3 on expression of tumor necrosis factor-alpha and chemokines by monocytes. J Food Sci. 2010; 75(6):H200-4. DOI: 10.1111/j.1750-3841.2010.01704.x. View

16.

Ross A, Manson J, Abrams S, Aloia J, Brannon P, Clinton S . The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2010; 96(1):53-8. PMC: 3046611. DOI: 10.1210/jc.2010-2704. View

17.

Pappa T, Vagenakis A, Alevizaki M . The nonthyroidal illness syndrome in the non-critically ill patient. Eur J Clin Invest. 2010; 41(2):212-20. DOI: 10.1111/j.1365-2362.2010.02395.x. View

18.

Kivity S, Agmon-Levin N, Zisappl M, Shapira Y, Nagy E, Danko K . Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol. 2011; 8(3):243-7. PMC: 4012880. DOI: 10.1038/cmi.2010.73. View

19.

Tamer G, Arik S, Tamer I, Coksert D . Relative vitamin D insufficiency in Hashimoto's thyroiditis. Thyroid. 2011; 21(8):891-6. DOI: 10.1089/thy.2009.0200. View

20.

Shelley B, Quasim T, Kinsella J, Talwar D, McMillan D . Low-serum 25-hydroxyvitamin D reflects severity of illness in critically ill patients. Crit Care Med. 2012; 40(8):2530. DOI: 10.1097/CCM.0b013e3182536a98. View