The Physiologic and Therapeutic Role of Heparin in Implantation and Placentation

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2015 Feb 6

PMID 25653897

Citations 12

Authors

Michela Quaranta

Offer Erez

Salvatore Andrea Mastrolia

Arie Koifman

Elad Leron

Tamar Eshkoli

Moshe Mazor

Gershon Holcberg

Affiliations

Soon will be listed here.

Abstract

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications known as the great obstetrical syndromes: preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture of membranes, preterm labor, and recurrent pregnancy loss. There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review, we will summarize the properties and the physiological contributions of heparins to the success of implantation, placentation and normal pregnancy.

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