Wireless Integrated Biosensors for Point-of-care Diagnostic Applications

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2015 Feb 5

PMID 25648709

Citations 18

Authors

Ebrahim Ghafar-Zadeh

Affiliations

Soon will be listed here.

Abstract

Recent advances in integrated biosensors, wireless communication and power harvesting techniques are enticing researchers into spawning a new breed of point-of-care (POC) diagnostic devices that have attracted significant interest from industry. Among these, it is the ones equipped with wireless capabilities that drew our attention in this review paper. Indeed, wireless POC devices offer a great advantage, that of the possibility of exerting continuous monitoring of biologically relevant parameters, metabolites and other bio-molecules, relevant to the management of various morbid diseases such as diabetes, brain cancer, ischemia, and Alzheimer's. In this review paper, we examine three major categories of miniaturized integrated devices, namely; the implantable Wireless Bio-Sensors (WBSs), the wearable WBSs and the handheld WBSs. In practice, despite the aforesaid progress made in developing wireless platforms, early detection of health imbalances remains a grand challenge from both the technological and the medical points of view. This paper addresses such challenges and reports the state-of-the-art in this interdisciplinary field.

Citing Articles

Silicon-Based Biosensors: A Critical Review of Silicon's Role in Enhancing Biosensing Performance.

Muhammad W, Song J, Kim S, Ahmed F, Cho E, Lee H Biosensors (Basel). 2025; 15(2).

PMID: 39997021 PMC: 11852904. DOI: 10.3390/bios15020119.

Novel interfaces for internet of wearable electrochemical sensors.

Shahzad S, Iftikhar F, Shah A, Rehman H, Iwuoha E RSC Adv. 2024; 14(49):36713-36732.

PMID: 39559568 PMC: 11570917. DOI: 10.1039/d4ra07165d.

Biopolymer-protected graphene-FeO nanocomposite based wearable microneedle sensor: toward real-time continuous monitoring of dopamine.

M R K, Panicker L, Narayan R, Kotagiri Y RSC Adv. 2024; 14(10):7131-7141.

PMID: 38414985 PMC: 10898425. DOI: 10.1039/d4ra00110a.

A Time-Division Multiplexing Multi-Channel Micro-Electrochemical Workstation with Carbon-Based Material Electrodes for Online L-Trosine Detection.

Bao Q, Li G, Yang Z, Wei J, Cheng W, Qu Z Sensors (Basel). 2023; 23(14).

PMID: 37514547 PMC: 10386381. DOI: 10.3390/s23146252.

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers.

Rao Bommi J, Kummari S, Lakavath K, Sukumaran R, Panicker L, Marty J Biosensors (Basel). 2023; 13(3).

PMID: 36979610 PMC: 10046866. DOI: 10.3390/bios13030398.

References

Bandiera L, Cellere G, Cagnin S, De Toni A, Zanoni E, Lanfranchi G . A fully electronic sensor for the measurement of cDNA hybridization kinetics. Biosens Bioelectron. 2006; 22(9-10):2108-14. DOI: 10.1016/j.bios.2006.09.025. View

Wilson D, Block J . Real-time continuous glucose monitor use and patient selection: what have we learned and where are we going?. Diabetes Technol Ther. 2005; 7(5):788-91. DOI: 10.1089/dia.2005.7.788. View

Ghafar-Zadeh E, Sawan M, Chodavarapu V, Hosseini-Nia T . Bacteria Growth Monitoring Through a Differential CMOS Capacitive Sensor. IEEE Trans Biomed Circuits Syst. 2013; 4(4):232-8. DOI: 10.1109/TBCAS.2010.2048430. View

Wang W, Kuo W, Huang H, Luo C . Wide dynamic range CMOS potentiostat for amperometric chemical sensor. Sensors (Basel). 2012; 10(3):1782-97. PMC: 3264451. DOI: 10.3390/s100301782. View

Roda A, Guardigli M, Calabria D, Calabretta M, Cevenini L, Michelini E . A 3D-printed device for a smartphone-based chemiluminescence biosensor for lactate in oral fluid and sweat. Analyst. 2014; 139(24):6494-501. DOI: 10.1039/c4an01612b. View

Aytur T, Foley J, Anwar M, Boser B, Harris E, Beatty P . A novel magnetic bead bioassay platform using a microchip-based sensor for infectious disease diagnosis. J Immunol Methods. 2006; 314(1-2):21-9. DOI: 10.1016/j.jim.2006.05.006. View

Zhou W, Dai X, Fu T, Xie C, Liu J, Lieber C . Long term stability of nanowire nanoelectronics in physiological environments. Nano Lett. 2014; 14(3):1614-9. PMC: 3960854. DOI: 10.1021/nl500070h. View

Ma H, Wallbank R, Chaji R, Li J, Suzuki Y, Jiggins C . An impedance-based integrated biosensor for suspended DNA characterization. Sci Rep. 2013; 3:2730. PMC: 3781400. DOI: 10.1038/srep02730. View

Tokarskyy O, Marshall D . Immunosensors for rapid detection of Escherichia coli O157:H7 - perspectives for use in the meat processing industry. Food Microbiol. 2007; 25(1):1-12. DOI: 10.1016/j.fm.2007.07.005. View

10.

Hammond P, Ali D, Cumming D . A system-on-chip digital pH meter for use in a wireless diagnostic capsule. IEEE Trans Biomed Eng. 2005; 52(4):687-94. DOI: 10.1109/TBME.2005.844041. View

11.

Rothberg J, Hinz W, Rearick T, Schultz J, Mileski W, Davey M . An integrated semiconductor device enabling non-optical genome sequencing. Nature. 2011; 475(7356):348-52. DOI: 10.1038/nature10242. View

12.

Daugherty E, Branson R, Deveraux A, Rubinson L . Infection control in mass respiratory failure: preparing to respond to H1N1. Crit Care Med. 2009; 38(4 Suppl):e103-9. DOI: 10.1097/CCM.0b013e3181c6697a. View

13.

Cruz A, Norena N, Kaushik A, Bhansali S . A low-cost miniaturized potentiostat for point-of-care diagnosis. Biosens Bioelectron. 2014; 62:249-54. DOI: 10.1016/j.bios.2014.06.053. View

14.

Lewitus D, Smith K, Landers J, Neimark A, Kohn J . Bioactive Agarose Carbon-Nanotube Composites are Capable of Manipulating Brain-Implant Interface. J Appl Polym Sci. 2014; 131(14). PMC: 4221857. DOI: 10.1002/app.40297. View

15.

Bereket W, Hemalatha K, Getenet B, Wondwossen T, Solomon A, Zeynudin A . Update on bacterial nosocomial infections. Eur Rev Med Pharmacol Sci. 2012; 16(8):1039-44. View

16.

Xiao Y, Lubin A, Baker B, Plaxco K, Heeger A . Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex. Proc Natl Acad Sci U S A. 2006; 103(45):16677-80. PMC: 1622927. DOI: 10.1073/pnas.0607693103. View

17.

Kruppa P, Frey A, Kuehne I, Schienle M, Persike N, Kratzmueller T . A digital CMOS-based 24×16 sensor array platform for fully automatic electrochemical DNA detection. Biosens Bioelectron. 2010; 26(4):1414-9. DOI: 10.1016/j.bios.2010.07.070. View

18.

Li L, Liu X, Qureshi W, Mason A . CMOS Amperometric Instrumentation and Packaging for Biosensor Array Applications. IEEE Trans Biomed Circuits Syst. 2013; 5(5):439-48. DOI: 10.1109/TBCAS.2011.2171339. View

19.

Ostrem J, Markun L, Glass G, Racine C, Volz M, Heath S . Effect of frequency on subthalamic nucleus deep brain stimulation in primary dystonia. Parkinsonism Relat Disord. 2014; 20(4):432-8. DOI: 10.1016/j.parkreldis.2013.12.012. View

20.

Hall D, Gaster R, Makinwa K, Wang S, Murmann B . A 256 pixel magnetoresistive biosensor microarray in 0.18μm CMOS. IEEE J Solid-State Circuits. 2014; 48(5):1290-1301. PMC: 3993911. DOI: 10.1109/JSSC.2013.2245058. View