Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2015 Feb 3

PMID 25642247

Citations 16

Authors

Peng Zhao

Wei Hu

Hongyun Wang

Shengyuan Yu

Chuzhong Li

Jiwei Bai

Songbai Gui

Yazhuo Zhang

Affiliations

Soon will be listed here.

Abstract

Pituitary adenomas, monoclonal in origin, are the most common intracranial neoplasms. Altered gene expression as well as somatic mutations is detected frequently in pituitary adenomas. The purpose of this study was to detect differentially expressed genes (DEGs) and biological processes during tumor formation of pituitary adenomas. We performed an integrated analysis of publicly available GEO datasets of pituitary adenomas to identify DEGs between pituitary adenomas and normal control (NC) tissues. Gene function analysis including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and protein-protein interaction (PPI) networks analysis was conducted to interpret the biological role of those DEGs. In this study we detected 3994 DEGs (2043 upregulated and 1951 downregulated) in pituitary adenoma through an integrated analysis of 5 different microarray datasets. Gene function analysis revealed that the functions of those DEGs were highly correlated with the development of pituitary adenoma. This integrated analysis of microarray data identified some genes and pathways associated with pituitary adenoma, which may help to understand the pathology underlying pituitary adenoma and contribute to the successful identification of therapeutic targets for pituitary adenoma.

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