Hedgehog Signaling in Prostate Epithelial-mesenchymal Growth Regulation

Overview

Journal Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2015 Feb 3

PMID 25641695

Citations 25

Authors

Yu-Ching Peng

Alexandra L Joyner

Affiliations

Soon will be listed here.

Abstract

The prostate gland plays an important role in male reproduction, and is also an organ prone to diseases such as benign prostatic hyperplasia (BPH) and prostate cancer. The prostate consists of ducts with an inner layer of epithelium surrounded by stroma. Reciprocal signaling between these two cell compartments is instrumental to normal prostatic development, homeostasis, regeneration, as well as tumor formation. Hedgehog (HH) signaling is a master regulator in numerous developmental processes. In many organs, HH plays a key role in epithelial-mesenchymal signaling that regulates organ growth and tissue differentiation, and abnormal HH signaling has been implicated in the progression of various epithelial carcinomas. In this review, we focus on recent studies exploring the multipotency of endogenous postnatal and adult epithelial and stromal stem cells and studies addressing the role of HH in prostate development and cancer. We discuss the implications of the results for a new understanding of prostate development and disease. Insight into the cellular and molecular mechanisms underlying epithelial-mesenchymal growth regulation should provide a basis for devising innovative therapies to combat diseases of the prostate.

Citing Articles

Deciphering the Tumor Microenvironment in Prostate Cancer: A Focus on the Stromal Component.

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Magnetic Resonance Elastography for the Detection and Classification of Prostate Cancer.

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Stromal androgen signaling governs essential niches in supporting prostate development and tumorigenesis.

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The multifaceted role of the stroma in the healthy prostate and prostate cancer.

Di Carlo E, Sorrentino C J Transl Med. 2024; 22(1):825.

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Capsaicin reduces blood glucose and prevents prostate growth by regulating androgen, RAGE/IGF-1/Akt, TGF-β/Smad signalling pathway and reversing epithelial-mesenchymal transition in streptozotocin-induced diabetic mice.

Sun H, Wang Z, Tu B, Shao Z, Li Y, Han D Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(10):7659-7671.

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References

Bonkhoff H, Stein U, Remberger K . Multidirectional differentiation in the normal, hyperplastic, and neoplastic human prostate: simultaneous demonstration of cell-specific epithelial markers. Hum Pathol. 1994; 25(1):42-6. DOI: 10.1016/0046-8177(94)90169-4. View

Banerjee P, Banerjee S, Tilly K, Tilly J, Brown T, Zirkin B . Lobe-specific apoptotic cell death in rat prostate after androgen ablation by castration. Endocrinology. 1995; 136(10):4368-76. DOI: 10.1210/endo.136.10.7664656. View

Hayward S, Cunha G, Dahiya R . Normal development and carcinogenesis of the prostate. A unifying hypothesis. Ann N Y Acad Sci. 1996; 784:50-62. DOI: 10.1111/j.1749-6632.1996.tb16227.x. View

Cunha G, Hayward S, Dahiya R, Foster B . Smooth muscle-epithelial interactions in normal and neoplastic prostatic development. Acta Anat (Basel). 1996; 155(1):63-72. DOI: 10.1159/000147791. View

Hayward S, Baskin L, Haughney P, Cunha A, Foster B, Dahiya R . Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicle. Acta Anat (Basel). 1996; 155(2):81-93. DOI: 10.1159/000147793. View

Hayward S, Baskin L, Haughney P, Foster B, Cunha A, Dahiya R . Stromal development in the ventral prostate, anterior prostate and seminal vesicle of the rat. Acta Anat (Basel). 1996; 155(2):94-103. DOI: 10.1159/000147794. View

Stone D, Hynes M, Armanini M, Swanson T, Gu Q, Johnson R . The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 1996; 384(6605):129-34. DOI: 10.1038/384129a0. View

Marigo V, Davey R, Zuo Y, Cunningham J, Tabin C . Biochemical evidence that patched is the Hedgehog receptor. Nature. 1996; 384(6605):176-9. DOI: 10.1038/384176a0. View

Nemeth J, Sensibar J, White R, Zelner D, Kim I, Lee C . Prostatic ductal system in rats: tissue-specific expression and regional variation in stromal distribution of transforming growth factor-beta 1. Prostate. 1997; 33(1):64-71. DOI: 10.1002/(sici)1097-0045(19970915)33:1<64::aid-pros11>3.0.co;2-j. View

10.

MOTOYAMA J, Takabatake T, Takeshima K, Hui C . Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nat Genet. 1998; 18(2):104-6. DOI: 10.1038/ng0298-104. View

11.

Perler F . Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution. Cell. 1998; 92(1):1-4. DOI: 10.1016/s0092-8674(00)80892-2. View

12.

Pepinsky R, Zeng C, Wen D, Rayhorn P, Baker D, Williams K . Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem. 1998; 273(22):14037-45. DOI: 10.1074/jbc.273.22.14037. View

13.

Hayward S, Haughney P, Rosen M, Greulich K, Weier H, Dahiya R . Interactions between adult human prostatic epithelium and rat urogenital sinus mesenchyme in a tissue recombination model. Differentiation. 1998; 63(3):131-40. DOI: 10.1046/j.1432-0436.1998.6330131.x. View

14.

MOTOYAMA J, Liu J, Mo R, Ding Q, Post M, Hui C . Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet. 1998; 20(1):54-7. DOI: 10.1038/1711. View

15.

Robinson E, Neal D, Collins A . Basal cells are progenitors of luminal cells in primary cultures of differentiating human prostatic epithelium. Prostate. 1998; 37(3):149-60. DOI: 10.1002/(sici)1097-0045(19981101)37:3<149::aid-pros4>3.0.co;2-e. View

16.

De Marzo A, Nelson W, Meeker A, Coffey D . Stem cell features of benign and malignant prostate epithelial cells. J Urol. 1998; 160(6 Pt 2):2381-92. DOI: 10.1097/00005392-199812020-00004. View

17.

MOTOYAMA J, Heng H, Crackower M, Takabatake T, Takeshima K, Tsui L . Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis. Mech Dev. 1998; 78(1-2):81-4. DOI: 10.1016/s0925-4773(98)00149-x. View

18.

Chang W, Wilson M, Birch L, Prins G . Neonatal estrogen stimulates proliferation of periductal fibroblasts and alters the extracellular matrix composition in the rat prostate. Endocrinology. 1999; 140(1):405-15. DOI: 10.1210/endo.140.1.6401. View

19.

Podlasek C, Barnett D, Clemens J, Bak P, Bushman W . Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium. Dev Biol. 1999; 209(1):28-39. DOI: 10.1006/dbio.1999.9229. View

20.

Sasaki H, Nishizaki Y, Hui C, Nakafuku M, Kondoh H . Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development. 1999; 126(17):3915-24. DOI: 10.1242/dev.126.17.3915. View