Tendon Functional Extracellular Matrix

Overview

Journal J Orthop Res

Publisher Wiley

Specialty Orthopedics

Date 2015 Feb 3

PMID 25640030

Citations 83

Authors

Hazel R C Screen

David E Berk

Karl E Kadler

Francesco Ramirez

Marian F Young

Affiliations

Soon will be listed here.

Abstract

This article is one of a series, summarizing views expressed at the Orthopaedic Research Society New Frontiers in Tendon Research Conference. This particular article reviews the three workshops held under the "Functional Extracellular Matrix" stream. The workshops focused on the roles of the tendon extracellular matrix, such as performing the mechanical functions of tendon, creating the local cell environment, and providing cellular cues. Tendon is a complex network of matrix and cells, and its biological functions are influenced by widely varying extrinsic and intrinsic factors such as age, nutrition, exercise levels, and biomechanics. Consequently, tendon adapts dynamically during development, aging, and injury. The workshop discussions identified research directions associated with understanding cell-matrix interactions to be of prime importance for developing novel strategies to target tendon healing or repair.

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