Maltese Mushroom (Cynomorium Coccineum L.) As Source of Oil with Potential Anticancer Activity

Overview

Journal Nutrients

Date 2015 Jan 29

PMID 25629557

Citations 10

Authors

Antonella Rosa

Mariella Nieddu

Alessandra Piras

Angela Atzeri

Danilo Putzu

Antonio Rescigno

Affiliations

Soon will be listed here.

Abstract

The present study aimed to examine the potential anticancer properties of fixed oil obtained from Maltese mushroom (Cynomorium coccineum L.), an edible, non-photosynthetic plant, used in traditional medicine of Mediterranean countries to treat various ailments and as an emergency food during the famine. We investigated the effect of the oil, obtained from dried stems by supercritical fractioned extraction with CO2, on B16F10 melanoma and colon cancer Caco-2 cell viability and lipid profile. The oil, rich in essential fatty acids (18:3n-3 and 18:2n-6), showed a significant growth inhibitory effect on melanoma and colon cancer cells. The incubation (24 h) with non-toxic oil concentrations (25 and 50 μg/mL) induced in both cancer cell lines a significant accumulation of the fatty acids 18:3n-3 and 18:2n-6 and an increase of the cellular levels of eicosapentaenoic acid (20:5n-3) with anticancer activity. Moreover, the oil exhibited the ability to potentiate the growth inhibitory effect of the antitumor drug 5-fluorouracil in Caco-2 cells and to influence the melanin content in B16F10 cells. The results qualify C. coccineum as a resource of oil, with potential benefits in cancer prevention, for nutraceutical and pharmaceutical applications.

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References

Lin L, Allemekinders H, Dansby A, Campbell L, Durance-Tod S, Berger A . Evidence of health benefits of canola oil. Nutr Rev. 2013; 71(6):370-85. PMC: 3746113. DOI: 10.1111/nure.12033. View

Chen J, Mark Stavro P, Thompson L . Dietary flaxseed inhibits human breast cancer growth and metastasis and downregulates expression of insulin-like growth factor and epidermal growth factor receptor. Nutr Cancer. 2003; 43(2):187-92. DOI: 10.1207/S15327914NC432_9. View

Soddu G, Sanjust E, Murgia S, Rescigno A . Interference of some tryptophan metabolites in the formation of melanin in vitro. Pigment Cell Res. 2004; 17(2):135-41. DOI: 10.1046/j.1600-0749.2003.00120.x. View

Carvalho M, Ferreira P, Mendes V, Silva R, Pereira J, Jeronimo C . Human cancer cell antiproliferative and antioxidant activities of Juglans regia L. Food Chem Toxicol. 2009; 48(1):441-7. DOI: 10.1016/j.fct.2009.10.043. View

Mateos R, Pereira-Caro G, Bacon J, Bongaerts R, Sarria B, Bravo L . Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells. J Agric Food Chem. 2013; 61(13):3264-9. DOI: 10.1021/jf305158q. View

de Oliveira M, Nunes-Pinheiro D, Tome A, Mota E, Lima-Verde I, Pinheiro F . In vivo topical anti-inflammatory and wound healing activities of the fixed oil of Caryocar coriaceum Wittm. seeds. J Ethnopharmacol. 2010; 129(2):214-9. DOI: 10.1016/j.jep.2010.03.014. View

Harper C, Edwards M, DeFilippis A, DeFilipis A, Jacobson T . Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr. 2005; 136(1):83-7. DOI: 10.1093/jn/136.1.83. View

Biondo P, Brindley D, Sawyer M, Field C . The potential for treatment with dietary long-chain polyunsaturated n-3 fatty acids during chemotherapy. J Nutr Biochem. 2008; 19(12):787-96. DOI: 10.1016/j.jnutbio.2008.02.003. View

El-Badry A, Mahmoud O, Harraz F . The effect of the aqueous extract of Cynomorium coccineum on the epididymal sperm pattern of the rat. Phytother Res. 1999; 13(3):248-50. DOI: 10.1002/(SICI)1099-1573(199905)13:3<248::AID-PTR425>3.0.CO;2-D. View

10.

Wang L, Chen J, Thompson L . The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenograftsis attributed to both its lignan and oil components. Int J Cancer. 2005; 116(5):793-8. DOI: 10.1002/ijc.21067. View

11.

Cui Z, Guo Z, Miao J, Wang Z, Li Q, Chai X . The genus Cynomorium in China: an ethnopharmacological and phytochemical review. J Ethnopharmacol. 2013; 147(1):1-15. DOI: 10.1016/j.jep.2013.01.020. View

12.

Tabolacci C, Lentini A, Mattioli P, Provenzano B, Oliverio S, Carlomosti F . Antitumor properties of aloe-emodin and induction of transglutaminase 2 activity in B16-F10 melanoma cells. Life Sci. 2010; 87(9-10):316-24. DOI: 10.1016/j.lfs.2010.07.003. View

13.

Ikram M, Dar M, Fakouhi T . Hypotensive agent from Cynomorium coccineum. Pahlavi Med J. 1978; 9(2):167-81. View

14.

Santos C, Schulze A . Lipid metabolism in cancer. FEBS J. 2012; 279(15):2610-23. DOI: 10.1111/j.1742-4658.2012.08644.x. View

15.

Giermasz A, Nowis D, Jalili A, Basak G, Marczak M, Makowski M . Antitumor activity of tributyrin in murine melanoma model. Cancer Lett. 2001; 164(2):143-8. DOI: 10.1016/s0304-3835(01)00375-5. View

16.

Al Ashaal H, Farghaly A, Abd El Aziz M, Ali M . Phytochemical investigation and medicinal evaluation of fixed oil of Balanites aegyptiaca fruits (Balantiaceae). J Ethnopharmacol. 2009; 127(2):495-501. DOI: 10.1016/j.jep.2009.10.007. View

17.

Singh S, Taneja M, Majumdar D . Biological activities of Ocimum sanctum L. fixed oil--an overview. Indian J Exp Biol. 2007; 45(5):403-12. View

18.

Schiller C, Kainz A, Mynett K, Gescher A . Assessment of viability of hepatocytes in suspension using the MTT assay. Toxicol In Vitro. 2010; 6(6):575-8. DOI: 10.1016/0887-2333(92)90070-8. View

19.

Park H, Han E, Park D . The ethyl acetate extract of PGP (Phellinus linteus grown on Panax ginseng) suppresses B16F10 melanoma cell proliferation through inducing cellular differentiation and apoptosis. J Ethnopharmacol. 2010; 132(1):115-21. DOI: 10.1016/j.jep.2010.07.052. View

20.

Al-Qarawi A, Abdel-Rahman H, El-Badry A, Harraz F, Razig N, Abdel-Magied E . The effect of extracts of Cynomorium coccineum and Withania somnifera on gonadotrophins and ovarian follicles of immature Wistar rats. Phytother Res. 2000; 14(4):288-90. DOI: 10.1002/1099-1573(200006)14:4<288::aid-ptr603>3.0.co;2-9. View