TRF2: TRansForming the View of General Transcription Factors

Overview

Journal Transcription

Specialty Molecular Biology

Date 2015 Jan 15

PMID 25588059

Citations 12

Authors

Yonathan Zehavi

Adi Kedmi

Diana Ideses

Tamar Juven-Gershon

Affiliations

Soon will be listed here.

Abstract

Transcriptional regulation is pivotal for development and differentiation of organisms. Transcription of eukaryotic protein-coding genes by RNA polymerase II (Pol II) initiates at the core promoter. Core promoters, which encompass the transcription start site, may contain functional core promoter elements, such as the TATA box, initiator, TCT and downstream core promoter element. TRF2 (TATA-box-binding protein-related factor 2) does not bind TATA box-containing promoters. Rather, it is recruited to core promoters via sequences other than the TATA box. We review the recent findings implicating TRF2 as a basal transcription factor in the regulation of diverse biological processes and specialized transcriptional programs.

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