Understanding Host-adherent-invasive Escherichia Coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Jan 13

PMID 25580435

Citations 34

Authors

Allison Agus

Sebastien Massier

Arlette Darfeuille-Michaud

Elisabeth Billard

Nicolas Barnich

Affiliations

Soon will be listed here.

Abstract

A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved with the host in a symbiotic relationship and some of them have developed strategies to promote their replication in the presence of competing microbiota. Recent evidence suggests that perturbation of the microbial community favors the emergence of opportunistic pathogens, in particular adherent-invasive Escherichia coli (AIEC) that can increase incidence and severity of gut inflammation in the context of Crohn's disease (CD). This review will report the importance of AIEC as triggers of intestinal inflammation, focusing on their impact on epithelial barrier function and stimulation of mucosal inflammation. Beyond manipulation of immune response, restoration of gut microbiota as a new treatment option for CD patients will be discussed.

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