Antimicrobial Peptides: a New Class of Antimalarial Drugs?

Overview

Journal Front Pharmacol

Date 2015 Jan 8

PMID 25566072

Citations 34

Authors

Nuno Vale

Luisa Aguiar

Paula Gomes

Affiliations

Soon will be listed here.

Abstract

A range of antimicrobial peptides (AMP) exhibit activity on malaria parasites, Plasmodium spp., in their blood or mosquito stages, or both. These peptides include a diverse array of both natural and synthetic molecules varying greatly in size, charge, hydrophobicity, and secondary structure features. Along with an overview of relevant literature reports regarding AMP that display antiplasmodial activity, this review makes a few considerations about those molecules as a potential new class of antimalarial drugs.

Citing Articles

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Antimalarial activity of cecropin antimicrobial peptides derived from mosquitoes.

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Antiplasmodial peptaibols act through membrane directed mechanisms.

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