Wound Healing and Skin Regeneration

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2015 Jan 7

PMID 25561722

Citations 236

Authors

Makoto Takeo

Wendy Lee

Mayumi Ito

Affiliations

Soon will be listed here.

Abstract

The skin is a complex organ consisting of the epidermis, dermis, and skin appendages, including the hair follicle and sebaceous gland. Wound healing in adult mammals results in scar formation without any skin appendages. Studies have reported remarkable examples of scarless healing in fetal skin and appendage regeneration in adult skin following the infliction of large wounds. The models used in these studies have offered a new platform for investigations of the cellular and molecular mechanisms underlying wound healing and skin regeneration in mammals. In this article, we will focus on the contribution of skin appendages to wound healing and, conversely, skin appendage regeneration following injuries.

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