Di-macrocyclic Terephthalamide Ligands As Chelators for the PET Radionuclide Zirconium-89

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2015 Jan 6

PMID 25556851

Citations 20

Authors

Darpan N Pandya

Sylvie Pailloux

David Tatum

Darren Magda

Thaddeus J Wadas

Affiliations

Soon will be listed here.

Abstract

The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.

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