Hyperbaric Oxygen Preconditioning Attenuates Hemorrhagic Transformation Through Increasing PPARγ in Hyperglycemic MCAO Rats

Overview

Journal Exp Neurol

Specialty Neurology

Date 2014 Dec 28

PMID 25542160

Citations 15

Authors

Hetao Bian

Qin Hu

Xiping Liang

Di Chen

Bo Li

Jiping Tang

John H Zhang

Affiliations

Soon will be listed here.

Abstract

Hyperbaric oxygen preconditioning (HBO-PC) has been demonstrated to attenuate hemorrhagic transformation (HT) after middle cerebral artery occlusion (MCAO) in hyperglycemic rats. However, the mechanisms remain to be illustrated. Recently, HBO-PC has been shown to activate peroxisome proliferator-activated receptor-gamma (PPARγ) by increasing 15d-PGJ2 in primary cultured neurons. We hypothesize that HBO-PC reduces HT by suppressing inflammation through increasing 15d-PGJ2 and activating PPARγ in hyperglycemic MCAO rats. HBO (2.5ATA) was administered for 1h daily for 5 consecutive days. The PPARγ inhibitor GW9662 was administered intraperitoneally to designated animals. Infarction volume, hemorrhage volume, neurological scores and mortality were analyzed. The levels of 15d-PGJ2, PPARγ, TNF-α and IL-1β, tight junction proteins as well as the activity of MMP-2 and MMP-9 were evaluated 24h after MCAO. HBO-PC reduced HT, improved neurological function, down-regulated inflammatory molecules and inhibited the activation of MMP-9 by increasing 15d-PGJ2 and PPARγ at 24h after MCAO. The results suggested that HBO-PC might be an alternative measure to decrease HT in ischemic stroke.

Citing Articles

Brain resident microglia in Alzheimer's disease: foe or friends.

Kaur S, K M, Sharma A, Giridharan V, Dandekar M Inflammopharmacology. 2024; 32(5):2781-2800.

PMID: 39167311 DOI: 10.1007/s10787-024-01550-8.

Human Serum Albumin-enriched Clopidogrel Bisulfate Nanoparticle Alleviates Cerebral Ischemia-Reperfusion Injury in Rats.

Luo Y, Xia Y, Zhang H, Lin Y, He L, Gong T Pharm Res. 2023; 40(7):1821-1833.

PMID: 37291463 DOI: 10.1007/s11095-023-03543-8.

Alterations in the gut microbiome with hemorrhagic transformation in experimental stroke.

Huang Q, Di L, Yu F, Feng X, Liu Z, Wei M CNS Neurosci Ther. 2021; 28(1):77-91.

PMID: 34591349 PMC: 8673707. DOI: 10.1111/cns.13736.

Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An Update.

Yu Q, Zhao T, Liu M, Cao D, Li J, Li Y Front Pharmacol. 2021; 12:707696.

PMID: 34526897 PMC: 8435574. DOI: 10.3389/fphar.2021.707696.

Hyperbaric Oxygen Preconditioning Protects Against Cerebral Ischemia/Reperfusion Injury by Inhibiting Mitochondrial Apoptosis and Energy Metabolism Disturbance.

Wang S, Fu Y, Han X, Yong Z, Li Q, Hu Z Neurochem Res. 2021; 46(4):866-877.

PMID: 33453006 DOI: 10.1007/s11064-020-03219-4.

References

Paciaroni M, Agnelli G, Caso V, Corea F, Ageno W, Alberti A . Acute hyperglycemia and early hemorrhagic transformation in ischemic stroke. Cerebrovasc Dis. 2009; 28(2):119-23. DOI: 10.1159/000223436. View

Hafez S, Coucha M, Bruno A, Fagan S, Ergul A . Hyperglycemia, acute ischemic stroke, and thrombolytic therapy. Transl Stroke Res. 2014; 5(4):442-453. PMC: 4112106. DOI: 10.1007/s12975-014-0336-z. View

Zhao X, Zhang Y, Strong R, Grotta J, Aronowski J . 15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. J Cereb Blood Flow Metab. 2005; 26(6):811-20. DOI: 10.1038/sj.jcbfm.9600233. View

Donnan G, Davis S, Parsons M, Ma H, Dewey H, Howells D . How to make better use of thrombolytic therapy in acute ischemic stroke. Nat Rev Neurol. 2011; 7(7):400-9. DOI: 10.1038/nrneurol.2011.89. View

Soejima Y, Ostrowski R, Manaenko A, Fujii M, Tang J, Zhang J . Hyperbaric oxygen preconditioning attenuates hyperglycemia enhanced hemorrhagic transformation after transient MCAO in rats. Med Gas Res. 2012; 2(1):9. PMC: 3351373. DOI: 10.1186/2045-9912-2-9. View

Cipolla M, Godfrey J . Effect of hyperglycemia on brain penetrating arterioles and cerebral blood flow before and after ischemia/reperfusion. Transl Stroke Res. 2010; 1(2):127-34. PMC: 2886303. DOI: 10.1007/s12975-010-0014-8. View

Garcia J, Wagner S, Liu K, Hu X . Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995; 26(4):627-34; discussion 635. DOI: 10.1161/01.str.26.4.627. View

Koch S . Moving towards preconditioning for neurological disorders: are we ready for clinical trials?. Transl Stroke Res. 2013; 4(1):15-8. DOI: 10.1007/s12975-012-0220-7. View

Nosjean O, Boutin J . Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part?. Cell Signal. 2002; 14(7):573-83. DOI: 10.1016/s0898-6568(01)00281-9. View

10.

Sundararajan S, Gamboa J, Victor N, Wanderi E, Lust W, Landreth G . Peroxisome proliferator-activated receptor-gamma ligands reduce inflammation and infarction size in transient focal ischemia. Neuroscience. 2004; 130(3):685-96. DOI: 10.1016/j.neuroscience.2004.10.021. View

11.

Fabian R, Kent T . Hyperglycemia accentuates persistent "functional uncoupling" of cerebral microvascular nitric oxide and superoxide following focal ischemia/reperfusion in rats. Transl Stroke Res. 2013; 3(4):482-90. DOI: 10.1007/s12975-012-0210-9. View

12.

Lehrke M, Lazar M . The many faces of PPARgamma. Cell. 2005; 123(6):993-9. DOI: 10.1016/j.cell.2005.11.026. View

13.

Shaul P, Campbell W, Farrar M, Magness R . Oxygen modulates prostacyclin synthesis in ovine fetal pulmonary arteries by an effect on cyclooxygenase. J Clin Invest. 1992; 90(6):2147-55. PMC: 443365. DOI: 10.1172/JCI116100. View

14.

Dezfulian C, Garrett M, Gonzalez N . Clinical application of preconditioning and postconditioning to achieve neuroprotection. Transl Stroke Res. 2013; 4(1):19-24. PMC: 4224593. DOI: 10.1007/s12975-012-0224-3. View

15.

Jadhav V, Ostrowski R, Tong W, Matus B, Jesunathadas R, Zhang J . Cyclo-oxygenase-2 mediates hyperbaric oxygen preconditioning-induced neuroprotection in the mouse model of surgical brain injury. Stroke. 2009; 40(9):3139-42. PMC: 2798800. DOI: 10.1161/STROKEAHA.109.549774. View

16.

Soejima Y, Hu Q, Krafft P, Fujii M, Tang J, Zhang J . Hyperbaric oxygen preconditioning attenuates hyperglycemia-enhanced hemorrhagic transformation by inhibiting matrix metalloproteinases in focal cerebral ischemia in rats. Exp Neurol. 2013; 247:737-43. PMC: 3742563. DOI: 10.1016/j.expneurol.2013.03.019. View

17.

Chiu C, Chen C, Shen C, Chin L, Ma H, Chuang H . Hyperglycemia exacerbates intracerebral hemorrhage via the downregulation of aquaporin-4: temporal assessment with magnetic resonance imaging. Stroke. 2013; 44(6):1682-9. DOI: 10.1161/STROKEAHA.113.675983. View

18.

Gillespie W, Tyagi N, Tyagi S . Role of PPARgamma, a nuclear hormone receptor in neuroprotection. Indian J Biochem Biophys. 2011; 48(2):73-81. View

19.

Lin T, Cheung W, Wu J, Chen J, Lin H, Chen J . 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol. 2005; 26(3):481-7. DOI: 10.1161/01.ATV.0000201933.53964.5b. View

20.

Pereira M, Hurtado O, Cardenas A, Alonso-Escolano D, Bosca L, Vivancos J . The nonthiazolidinedione PPARgamma agonist L-796,449 is neuroprotective in experimental stroke. J Neuropathol Exp Neurol. 2005; 64(9):797-805. DOI: 10.1097/01.jnen.0000178852.83680.3c. View