An Extra Breath of Fresh Air: Hyperbaric Oxygenation As a Stroke Therapeutic

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2020 Sep 9

PMID 32899709

Citations 13

Authors

Blaise Cozene

Nadia Sadanandan

Bella Gonzales-Portillo

Madeline Saft

Justin Cho

You Jeong Park

Cesar V Borlongan

Affiliations

Soon will be listed here.

Abstract

Stroke serves as a life-threatening disease and continues to face many challenges in the development of safe and effective therapeutic options. The use of hyperbaric oxygen therapy (HBOT) demonstrates pre-clinical effectiveness for the treatment of acute ischemic stroke and reports reductions in oxidative stress, inflammation, and neural apoptosis. These pathophysiological benefits contribute to improved functional recovery. Current pre-clinical and clinical studies are testing the applications of HBOT for stroke neuroprotection, including its use as a preconditioning regimen. Mild oxidative stress may be able to prime the brain to tolerate full extensive oxidative stress that occurs during a stroke, and HBOT preconditioning has displayed efficacy in establishing such ischemic tolerance. In this review, evidence on the use of HBOT following an ischemic stroke is examined, and the potential for HBOT preconditioning as a neuroprotective strategy. Additionally, HBOT as a stem cell preconditioning is also discussed as a promising strategy, thus maximizing the use of HBOT for ischemic stroke.

Citing Articles

Linc00205/Mir-495-3p/Tnfsf15 Axis is Implicated in the Treatment Effect of Hyperbaric Oxygen Therapy on Patients with Post-Stroke Cognitive Impairment.

Yang X, Chen M, Shen Z, Rong T, Feng J, Wu M Noro Psikiyatr Ars. 2025; 62(1):11-19.

PMID: 40046208 PMC: 11877386. DOI: 10.29399/npa.28530.

Hyperbaric Oxygen Therapy in Children with Brain Injury: A Retrospective Case Series.

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Tong Y, Chen Y, Yu Y, Wang F, Lin L, He G BMC Neurol. 2025; 25(1):14.

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Endothelial Dysfunction and Cardiovascular Disease: Hyperbaric Oxygen Therapy as an Emerging Therapeutic Modality?.

Batinac T, Baticic L, Krsek A, Knezevic D, Marcucci E, Sotosek V J Cardiovasc Dev Dis. 2024; 11(12).

PMID: 39728298 PMC: 11677558. DOI: 10.3390/jcdd11120408.

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