Synthesis of Polysubstituted Pyrroles Via Pd-catalyzed Oxidative Alkene C-H Bond Arylation and Amination

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2014 Dec 24

PMID 25536027

Citations 5

Authors

Jia Zheng

Liangbin Huang

Chuyu Huang

Wanqing Wu

Huanfeng Jiang

Affiliations

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Abstract

A novel Pd(II)-catalyzed oxidative approach to construct polysubstituted pyrroles from N-homoallylicamines and arylboronic acids was developed. This transformation is supposed to proceed through cascade formation of C-C and C-N bonds via oxidative arylation of unactive alkenes, followed by intramolecular aza-Wacker cyclization.

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